Search results

Publication date Communities Collections Article title Author(s)
7 Jun 2019 BMRC Experimental Drug Development Centre Backbone resonance assignment for the full length tRNA-(N1G37) methyltransferase of Pseudomonas aeruginosa Yan Li, Wenhe Zhong, Ann Zhufang Koay, Hui Qi Ng, Qianhui Nah, Yee Hwa Wong, Jeffrey Hill, Julien Lescar, Peter C. Dedon, CongBao Kang
8 Oct 2018 BMRC Experimental Drug Development Centre Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase Yan Li, Wenhe Zhong, Ann Zhufang Koay, Hui Qi Ng, Xiaoying Koh-Stenta, Qianhui Nah, Siau Hoi Lim, Andreas Larsson, Julien Lescar, Jeffrey Hill, Peter C. Dedon, CongBao Kang
21 Sep 2018 BMRC Experimental Drug Development Centre Expression, purification of Zika virus membrane protein-NS2B in detergent micelles for NMR studies Elizabeth Yihui Ng, Ying Ru Loh, Yan Li, Qingxin Li, CongBao Kang
21 Jun 2018 BMRC Experimental Drug Development Centre Characterization of molecular interactions between Zika virus protease and peptides derived from the C-terminus of NS2B Yan Li, Ying Ru Loh, Alvin Wei Hung, CongBao Kang
23 May 2018 BMRC Experimental Drug Development Centre Structural and ligand binding analysis of the YAP-binding domain of transcription factor TEAD4 Yan Li, Shuang Liu, Elizabeth Yihui Ng, Rong Li, Anders Poulsen, Jeffrey Hill, CongBao Kang, Ajaybabu Pobbati, Alvin Wei Hung, Wanjin Hong, Thomas Keller
11 May 2018 BMRC Bioinformatics Institute Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH2 Qiu Ying Lau, Jianguo Li, Marc-Antoine Sani, Sheetal Sinha, Yan Li, Fui Mee Ng, CongBao Kang, Surajit Bhattacharjya, Frances Separovic, Chandra Verma, Cheng San Brian Chia
6 Feb 2018 BMRC Experimental Drug Development Centre Structural insights into the inhibition of Zika virus NS2B-NS3 protease by a small molecule inhibitor Kassoum Nacro, Yan Li, Zhenzhen Zhang, Ying Ru Loh, Rong Li, Hai Yan Yang, Anna Jansson, Jeffrey Hill, Thomas Keller, Dahai Luo, CongBao Kang
18 Oct 2017 BMRC Experimental Drug Development Centre Secondary Structure and Membrane Topology of Dengue Virus NS4A Protein in Micelles Yan Li, Michelle Yueqi Lee, Ying Ru Loh, CongBao Kang
23 Aug 2017 BMRC Experimental Drug Development Centre Solution NMR Spectroscopy in Target-Based Drug Discovery Yan Li, CongBao Kang
14 Aug 2017 BMRC Experimental Drug Development Centre Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor Thomas Hugo Keller, CongBao Kang, Yan Li, Hui Qi Ng, Anna Ngo, Joma Joy, Jeffrey Hill, Pearlyn Kwek, Alvin Hung
5 Aug 2017 BMRC Experimental Drug Development Centre Zika Virus Protease: An Antiviral Drug Target CongBao Kang, Thomas Keller, Dahai Luo
20 Jul 2017 BMRC Experimental Drug Development Centre Structural characterization of the linked NS2B-NS3 protease of Zika virus Wint Wint Phoo, Weiling Wang, Ying Ru Loh, Zhenzhen Zhang, Elizabeth Yihui Ng, Thomas Hugo Keller, Dahai Luo, CongBao Kang, Yan Li
6 Jul 2017 BMRC Experimental Drug Development Centre Structural dynamics of Zika virus NS2B-NS3 protease binding to dipeptide inhibitors Ying Ru Loh, Weiling Wang, Alvin Wei Hung, Thomas Hugo Keller, Dahai Luo, CongBao Kang, Yan Li, Zhenzhen Zhang, Wint Wint Phoo, Shuang Liu, Ming Wei Chen
23 Dec 2016 BMRC Experimental Drug Development Centre Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus Yan Li, Ying Ru Loh, Wint Wint Phoo, Alvin Hung, CongBao Kang, Dahai Luo, Zhenzhen Zhang
15 Nov 2016 BMRC Experimental Drug Development Centre Structure of the NS2B-NS3 Protease from Zika Virus Caught after Self-Cleavage CongBao Kang, Dahai Luo, Wint Wint Phoo, Yan Li, Zhenzhen Zhang, Michelle Yueqi Lee, Ying Ru Loh, Yaw Bia Tan, Elizabeth Yihui Ng, Julien Lescar
18 Oct 2016 BMRC Experimental Drug Development Centre A Phenotypic Screen for Small-Molecule Inhibitors of Constitutively Active Mutant Thrombopoietin Receptor Implicated in Myeloproliferative Neoplasms. Zhufang Ann Koay, Christian Pecquet, Carmen Diaconu, Yasmine Ould-Amer, CongBao Kang, Anders Poulsen, May Ann Lee, David Jenkins, Andrew Shiau, Stefan Constantinescu, Anna Ngo, Meng Ling Choong
24 Aug 2016 BMRC Experimental Drug Development Centre Secondary structure and membrane topology of the full length Dengue Virus NS4B in micelles Yan Li, Ying Lei Wong, Michelle Yueqi Lee, Qingxin Li, Qing-Yin Wang, Julien Lescar, CongBao Kang, Pei-Yong Shi
30 Jun 2016 BMRC Experimental Drug Development Centre Escherichia coli topoisomerase IV E subunit and an inhibitor binding mode revealed by NMR spectroscopy Yan Li, Ying Lei Wong, Fui Mee Ng, Boping Liu, Yun Xuan Wong, Zhin Ying Poh, Shuang Liu, Siew Wen Then, Michelle Yueqi Lee, Hui Qi Ng, Qiwei Huang, Alvin W Hung, Joseph Cherian, Jeffrey Hill, Thomas H Keller, CongBao Kang
30 Mar 2016 BMRC Experimental Drug Development Centre Structure of the transmembrane domain of human nicastrin-a component of γ-secretase Yan Li, Lynette Sin Yee Liew, Qingxin Li, CongBao Kang
3 Feb 2016 BMRC Experimental Drug Development Centre Selection of suitable detergents for obtaining an active dengue protease in its natural form from E. coli Lynette Sin Yee Liew, Micelle Yueqi Lee, Ying Lei Wong, Jinting Cheng, Qingxin Li, CongBao Kang
18 Jan 2016 BMRC Experimental Drug Development Centre Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome Yan Li, Hui Qi Ng, Qingxin Li, CongBao Kang
4 Nov 2015 BMRC Experimental Drug Development Centre Biophysical studies of type II topoisomerases from Pseudomonas aeruginosa and Streptococcus pneumoniae substantiate their binding modes to a bis-pyridylurea inhibitor. Boping Liu, CongBao Kang, Yan Li, Joseph Cherian, Hui Qi Ng, Michelle Yueqi Lee, Nur Huda Ahmad, Zhi Ying Poh, Yun Xuan Wong, Qiwei Huang, Ying Lei Wong, Alvin Hung, Jeffrey Hill, Thomas Keller
22 Oct 2015 BMRC Institute of Molecular and Cell Biology Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy Guo-Ying Chen, CongBao Kang, Cheng San Brian Chia, Xuelian Luo, Wanjin Hong, Anders Poulsen, Ajaybabu V. Pobbati, Xiao Han, Alvin W. Hung, Seetoh Weiguang, Nur Huda
19 Oct 2015 BMRC Experimental Drug Development Centre Backbone assignment of the N-terminal 24-kDa fragment of Escherichia coli topoisomerase IV ParE subunit Yan Li, Ying Lei Wong, Michelle Yueqi Lee, Hui Qi Ng, CongBao Kang
17 Oct 2015 BMRC Experimental Drug Development Centre Characterization of the interaction between E. coli topoisomerase IV E subunit and an ATP competitive inhibitor. Thomas Hugo Keller, CongBao Kang, Yan Li, Ying Lei Wong, Fui Mee Ng, Boping Liu, Yun Xuan Wong, Zhi Ying Poh, Siew Wen Then, Michelle Lee, Hui Qi Ng, Alvin Hung, Joseph Cherian, Jeffrey Hill
25 Sep 2015 BMRC Experimental Drug Development Centre Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids Yan Li, Xuping Xie, Qiwei Huang, Julien Lescar, Pei-Yong Shi, CongBao Kang, Young Mee Kim, Jing Zou, Qing-Yin Wang, Shovanlal Gayen, Ying Lei Wong, Le Tian Lee
28 Aug 2015 BMRC Experimental Drug Development Centre Solution structure of the transmembrane domain of the mouse erythropoietin receptor in detergent micelles. Qingxin Li, Ying Lei Wong, Michelle Yueqi Lee, Yan Li, CongBao Kang
10 Aug 2015 BMRC Experimental Drug Development Centre NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor. Yan Li, Yun Xuan Wong, Zhi Ying Poh, Ying Lei Wong, Michelle Yueqi Lee, Hui Qi Ng, Boping Liu, Alvin Hung, Joseph Cherian, Jeffrey Hill, Thomas Hugo Keller, CongBao Kang
24 Jun 2015 BMRC Experimental Drug Development Centre Application of Fragment-Based Drug Discovery against DNA Gyrase B Cheng San Brian Chia, Qiu Ying Lau, Jeffrey Hill, Alvin Hung, Thomas Keller, Siew Wen Then, Nur Huda Ahmad, Ying Lei Wong, Hui Qi Ng, Guo-Ying Chen, Fui Mee Ng, Yih Wan Tan, Anders Poulsen, Wei Guang Seetoh, Grace Lin, CongBao Kang
11 Jun 2015 BMRC Experimental Drug Development Centre Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy Yan Li, Qingxin Li, Ying Lei Wong, Lynette Sin Yee Liew, CongBao Kang
29 May 2015 BMRC Experimental Drug Development Centre Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport. Hui Ting Toh, CongBao Kang, Neelagandan Kamariah, Chi Li, Kwanghee Baek, Huiya Huang, Carl White, Sreekanth Rajan, Minjoo Choi, Quoc Toan Nguyen, Hong Ye, Gerhard Gruber, Ho Sup Yoon
27 May 2015 BMRC Experimental Drug Development Centre Discovery of dengue virus NS4B inhibitors Qing-Yin Wang, Hongping Dong, Bin Zou, CongBao Kang, Karuna Ratna, Kah Fei Wan, Agatha Susila, Andy Yip, Chao Shan, Julien Lescar, Francesca Blasco, Paul Smith, Pei-Yong Shi
1 Apr 2015 BMRC Experimental Drug Development Centre Determinants of dengue virus NS4A protein oligomerization CongBao Kang, Pei-Yong Shi
14 Jan 2015 BMRC Experimental Drug Development Centre Mapping the interactions between the NS4B and NS3 proteins of dengue virus CongBao Kang, Pei-Yong Shi, Julien Lescar
7 Jan 2015 BMRC Experimental Drug Development Centre Characterization of dengue virus NS4A and NS4B protein interaction CongBao Kang, Pei-Yong Shi, Michelle Yueqi Lee
20 Oct 2014 BMRC Experimental Drug Development Centre Structural insight into the transmembrane segments 3 and 4 of the hERG potassium channel. Qingxin Li, Ying Lei Wong, Hui Qi Ng, Shovanlal Gayen, CongBao Kang
15 Oct 2014 BMRC Experimental Drug Development Centre Structural Insight into the Transmembrane Domain and the Juxta-membrane Region of the Erythropoietin Receptor in Micelles Qingxin Li, Ying Lei Wong, Qiwei Huang, CongBao Kang
17 Apr 2012 BMRC Experimental Drug Development Centre Expression and purification of the p75 neurotrophin receptor transmembrane domain using a ketosteroid isomerase tag Chen Angela Shuyi, Shovanlal Gayen, CongBao Kang, Qingxin Li