Dominant Negative TRAF3 Variant with Recurrent Mycobacterium abscessus Infection and Bronchiectasis

Page view(s)
344
Checked on Jul 18, 2024
Dominant Negative TRAF3 Variant with Recurrent Mycobacterium abscessus Infection and Bronchiectasis
Title:
Dominant Negative TRAF3 Variant with Recurrent Mycobacterium abscessus Infection and Bronchiectasis
Journal Title:
Open Forum Infectious Diseases
Publication Date:
03 August 2022
Citation:
Liew, M. F., Lim, H. F., Liang, M. C., Lim, I., Tan, Z., Tan, R. Y. M., Sam, Q. H., Soe, W. M., Tay, S. H., Xu, S., Chang, M. W., Foo, R., Soong, T. W., Ravikumar, S., & Chai, L. Y. A. (2022). Dominant Negative TRAF3 Variant with Recurrent Mycobacterium abscessus Infection and Bronchiectasis. Open Forum Infectious Diseases, 9(8). https://doi.org/10.1093/ofid/ofac379
Abstract:
Abstract Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12–interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor associated factor 3 (TRAF3) R338W variant in a patient with recurrent PNTM infection, demonstrating TRAF3- and TNF-α-deficient phenotypes via ex vivo immune and cloning-transfection cellular studies.
License type:
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Funding Info:
There was no specific funding for the research done
Description:
This is the version of record an article accepted for publication in Open Forum Infectious Diseases following peer review. The version of record Liew, M. F., Lim, H. F., Liang, M. C., Lim, I., Tan, Z., Tan, R. Y. M., Sam, Q. H., Soe, W. M., Tay, S. H., Xu, S., Chang, M. W., Foo, R., Soong, T. W., Ravikumar, S., & Chai, L. Y. A. (2022). Dominant Negative TRAF3 Variant with Recurrent Mycobacterium abscessus Infection and Bronchiectasis. Open Forum Infectious Diseases, 9(8). https://doi.org/10.1093/ofid/ofac379 is available online at: https://doi.org/10.1093/ofid/ofac379
ISSN:
2328-8957