Multimodal metabolomics pinpoint new metabolic vulnerability in colorectal cancer

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Multimodal metabolomics pinpoint new metabolic vulnerability in colorectal cancer
Title:
Multimodal metabolomics pinpoint new metabolic vulnerability in colorectal cancer
Journal Title:
Nature Metabolism
Publication Date:
14 August 2023
Citation:
Lee, M. Y., & Tam, W. L. (2023). Multimodal metabolomics pinpoint new metabolic vulnerability in colorectal cancer. Nature Metabolism, 5(8), 1255–1257. https://doi.org/10.1038/s42255-023-00852-5
Abstract:
By combining multimodal metabolomics technologies to investigate colorectal tissues and tumours in situ, Vande Voode et al. found tumour genotype-specific metabolic profiles and revealed the methionine-cycle enzyme AHCY to be a potential therapeutic target in colorectal cancer.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the National Medical Research Council, Singapore - Open Fund - Individual Research Grant
Grant Reference no. : OFIRG21nov-0068

This research / project is supported by the National Medical Research Council, Singapore - Open Fund - Individual Research Grant
Grant Reference no. : OFIRG19nov-0106

This research / project is supported by the National Medical Research Council, Singapore - CTG-Investigator-Initiated Trials
Grant Reference no. : CTGIIT18may0012

This research / project is supported by the National Medical Research Council, Singapore - Open Fund - Large Collaborative Grant
Grant Reference no. : NMRC/OFLCG/002-2018

This research / project is supported by the National Medical Research Council, Singapore - Open Fund - Large Collaborative Grant
Grant Reference no. : MOH-OFLCG21jun-0001

This research / project is supported by the National Research Foundation, Singapore - National Research Foundation-Investigatorship
Grant Reference no. : NRF-NRFI08-2022

This research / project is supported by the National Research Foundation, Singapore - Competitive Research Program
Grant Reference no. : NRF-CRP22-2019-0003

This research / project is supported by the National Research Foundation, Singapore - Competitive Research Program
Grant Reference no. : NRF-CRP23-2019-0004

This research / project is supported by the A*STAR - Career Development Fund
Grant Reference no. : C210812014

This research / project is supported by the Ministry of Education - Research Centres of Excellence initiative
Grant Reference no. : N.A
Description:
This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1038/s42255-023-00852-5
ISSN:
2522-5812
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