A new foe in folate metabolism

Page view(s)
26
Checked on May 22, 2024
A new foe in folate metabolism
Title:
A new foe in folate metabolism
Journal Title:
Nature Metabolism
Publication Date:
19 November 2021
Citation:
Wu, Z., & Tam, W. L. (2021). A new foe in folate metabolism. Nature Metabolism, 3(11), 1436–1438. https://doi.org/10.1038/s42255-021-00474-9
Abstract:
Two studies unmask the essentiality of methionine synthase activity in powering the folate cycle to replenish the tetrahydrofolate pool from 5-methyltetrahydrofolate; this generates nucleotides that support tumour growth. Dietary manipulation alters folate availability and holds implications for anti-cancer therapy response.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the National Medical Research Council - Open Fund - Individual Research Grant
Grant Reference no. : OFIRG17may061

This research / project is supported by the National Medical Research Council - Open Fund - Individual Research Grant
Grant Reference no. : OFIRG19nov-0106

This research / project is supported by the National Medical Research Council - CTG-Investigator-Initiated Trials
Grant Reference no. : CTGIIT18may0012

This research / project is supported by the National Medical Research Council - Clinician Scientist Individual Research Grant
Grant Reference no. : NMRC/CIRG/1470/2017

This research / project is supported by the National Medical Research Council - Open Fund - Large Collaborative Grant
Grant Reference no. : NMRC/ OFLCG/002-2018

This research / project is supported by the National Medical Research Council - Translational and Clinical Research (TCR) Flagship Programme
Grant Reference no. : NMRC/TCR15Jun006

This research / project is supported by the National Research Foundation - NRF Fellowship
Grant Reference no. : NRF-NRFF2015-04

This research / project is supported by the National Research Foundation - Competitive Research Programme
Grant Reference no. : NRF-CRP22-2019-0003

This research / project is supported by the National Research Foundation - Competitive Research Programme
Grant Reference no. : NRF-CRP23-2019-0004

This research / project is supported by the Ministry of Education (MOE) - Research Centers of Excellence initiative
Grant Reference no. : N.A
Description:
This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1038/s42255-021-00474-9
ISSN:
2522-5812
Files uploaded: