Ramakrishna, N. B., & Alberio, R. (2022). In preprints: towards reconstituting an ovary. Development, 149(21). https://doi.org/10.1242/dev.201354
Abstract:
Efforts towards the in vitro derivation of germ cells from stem cells have seen considerable progress in the past decade. The successful generation of oocytes in vitro, although challenging, will bring a major advance to reproductive biology – from understanding the complex developmental mechanisms of human oogenesis, to applications in disease modelling of infertility. Current attempts to achieve germ cell and somatic gonadal differentiation in vitro involve two key approaches: application of exogenous signals for induced differentiation paired with gonadal soma co-culture and, more recently, overexpression of candidate regulators. Here, we highlight two preprints that progress the in vitro differentiation of human female gonadal cells and oogonia.
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Publisher Copyright
Funding Info:
Supported by the Biotechnology and Biological Sciences Research
Council [BB/T013575/1] and A*STAR National Science Scholarship
research fellowship.