Lam, H. Y., Tergaonkar, V., Kumar, A. P., & Ahn, K. S. (2021). Mast cells: Therapeutic targets for COVID‐19 and beyond. IUBMB Life, 73(11), 1278–1292. Portico. https://doi.org/10.1002/iub.2552
Abstract:
Mast cells (MCs) are innate immune cells that widely distribute throughout all tissues and express a variety of cell surface receptors. Upon activation, MCs can rapidly release a diverse array of preformed mediators residing within their secretory granules and newly synthesize a broad spectrum of inflammatory
and immunomodulatory mediators. These unique features of MCs enable them to act as sentinels in response to rapid changes within their microenvironment. There is increasing evidence now that MCs play prominent roles in other pathophysiological processes besides allergic inflammation. In this review, we highlight the recent findings on the emerging roles of MCs in the pathogenesis of coronavirus disease-2019 (COVID-19) and discuss the potential of MCs as novel therapeutic targets for COVID-19 and other non-allergic inflammatory diseases.
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Funding Info:
This research / project is supported by the A*STAR - SINGA Scholarship
Grant Reference no. : N.A
This research / project is supported by the Singapore Ministry of Education, National Medical Research Council of Singapore - Tier 2
Grant Reference no. : MOE-T2EP30120-0016
This work was also supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (NRF-2021R1I1A2060024)
This research / project is supported by the National Research Foundation - Competitive Research Program
Grant Reference no. : NRF-CRP17-2017-02
Description:
This is the peer reviewed version of the following article: Lam, H. Y., Tergaonkar, V., Kumar, A. P., & Ahn, K. S. (2021). Mast cells: Therapeutic targets for COVID‐19 and beyond. IUBMB Life, 73(11), 1278–1292. Portico. https://doi.org/10.1002/iub.2552, which has been published in final form at https://doi.org/10.1002/iub.2552. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions