Unraveling B cell trajectories at single cell resolution

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Unraveling B cell trajectories at single cell resolution
Title:
Unraveling B cell trajectories at single cell resolution
Journal Title:
Trends in Immunology
Publication Date:
25 January 2022
Citation:
Morgan, D., & Tergaonkar, V. (2022). Unraveling B cell trajectories at single cell resolution. Trends in Immunology. https://doi.org/10.1016/j.it.2022.01.003
Abstract:
During adaptive immunity, B cells differentiate either into memory B cells or plasma cells and produce antibodies against foreign antigens to fight infection. Additionally, they behave as antigen-presenting cells and participate in T cell activation during cellular immune responses. However, their functional dysregulation can result in various autoimmune diseases and cancers. With significant breakthroughs in single cell technologies, assessing individual B cell genomics, transcriptomics, and proteomics can give deeper insights into mammalian B cell development, differentiation, antibody repertoire, and responses under conditions of homeostasis, infection, and aberrations during disease. In this review, we discuss the adoption of single cell approaches to identify different B cell gene signatures and biomarkers in normal and diseased tissues, and subsequent benefits for future therapeutic discoveries.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research / project is supported by the National Research Foundation - Competitive Research Program
Grant Reference no. : NRF-CRP17-2017-22
Description:
ISSN:
1471-4906