Hiu Yan Lam, Vinay Tergaonkar, Kwang Seok Ahn; Mechanisms of allergen-specific immunotherapy for allergic rhinitis and food allergies. Biosci Rep 30 April 2020; 40 (4): BSR20200256. doi: https://doi.org/10.1042/BSR20200256
Allergen-specific immunotherapy (AIT) is currently the only potential treatment for allergies including allergic rhinitis (AR) and food allergies (FA) that can modify the underlying course of the diseases. Although AIT has been performed for over a century, the precise and detailed mechanism for AIT is still unclear. Previous clinical trials have reported that successful AIT induces the reinstatement of tolerance against the specific allergen. In this review, we aim to provide an updated summary of the knowledge on the underlying mechanisms of IgE-mediated AR and FA as well as the immunological changes observed after AIT and discuss on how better understanding of these can lead to possible identification of biomarkers and novel strategies for AIT.
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) [grant number NRF-2018R1D1A1B07042969] and by the national Research Foundation (NRF) grant funded by the National Research Foundation, Singapore [grant number NRF-CRP17-2017-02]. Hiu Yan LAM was supported by the SINGA scholarship from Agency for Science, Technology and Research (A*STAR), Singapore.