Control of Adipogenesis by the Autocrine Interplays Between Angiotensin 1-7/Mas Receptor and Angiotensin II/AT1 Receptor Signaling Pathways

Control of Adipogenesis by the Autocrine Interplays Between Angiotensin 1-7/Mas Receptor and Angiotensin II/AT1 Receptor Signaling Pathways
Title:
Control of Adipogenesis by the Autocrine Interplays Between Angiotensin 1-7/Mas Receptor and Angiotensin II/AT1 Receptor Signaling Pathways
Other Titles:
Journal of Biological Chemistry
Publication Date:
16 April 2013
Citation:
Than A, Leow MK, Chen P. Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor signaling pathways. J Biol Chem. 2013;288(22):15520‐15531. doi:10.1074/jbc.M113.459792
Abstract:
Angiotensin II (AngII), a peptide hormone released by adipocytes, can be catabolized by adipose angiotensin-converting enzyme 2 (ACE2) to form Ang(1-7). Co-expression of AngII receptors (AT1 and AT2) and Ang(1-7) receptors (Mas) in adipocytes implies the autocrine regulation of the local angiotensin system upon adipocyte functions, through yet unknown interactive mechanisms. In the present study, we reveal the adipogenic effects of Ang(1-7) through activation of Mas receptor and its subtle interplays with the antiadipogenic AngII-AT1 signaling pathways. Specifically, in human and 3T3-L1 preadipocytes, Ang(1-7)-Mas signaling promotes adipogenesis via activation of PI3K/Akt and inhibition of MAPK kinase/ERK pathways, and Ang(1-7)-Mas antagonizes the antiadipogenic effect of AngII-AT1 by inhibiting the AngII-AT1-triggered MAPK kinase/ERK pathway. The autocrine regulation of the AngII/AT1-ACE2-Ang(1-7)/Mas axis upon adipogenesis has also been revealed. This study suggests the importance of the local regulation of the delicately balanced angiotensin system upon adipogenesis and its potential as a novel therapeutic target for obesity and related metabolic disorders.
License type:
PublisherCopyrights
Funding Info:
Singapore Ministry of Health National Medical Research Council under its EDG grant (NMRC/EDG/1048/2011)
Description:
This research was originally published in the Journal of Biological Chemistry. Aung Than, Melvin Khee-Shing Leow, and Peng Chen. Control of Adipogenesis by the Autocrine Interplays between Angiotensin 1–7/Mas Receptor and Angiotensin II/AT1 Receptor Signaling Pathways. J Biol Chem. 2013; 288:15520-15531. © the American Society for Biochemistry and Molecular Biology.
ISSN:
0021-9258
1083-351X
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