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18 Jun 2021
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BMRC
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Singapore Institute for Clinical Sciences
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Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children
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Mya Thway Tint,
Navin Michael,
Suresh Anand Sadananthan,
Jonathan Yinhao Huang,
Chin Meng Khoo,
Keith M Godfrey,
Lynette Pei-chi Shek,
Ngee Lek,
Kok Hian Tan,
Fabian Yap,
S Sendhil Velan,
Peter D Gluckman,
Yap-Seng Chong,
Neerja Karnani,
Shiao-Yng Chan,
Melvin Khee-Shing Leow,
Kuan Jin Lee,
Yung-Seng Lee,
Houchun Harry Hu,
Cuilin Zhang,
Marielle V Fortier,
Johan G Eriksson
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The Journal of Clinical Endocrinology & Metabolism
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15 Apr 2020
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BMRC
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Singapore Institute for Clinical Sciences
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Serum albumin cysteine trioxidation is a potential oxidative stress biomarker of type 2 diabetes mellitus
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Selvam Paramasivan,
Sunil S. Adav,
So Fong Cam Ngan,
Rinkoo Dalan,
Melvin Khee-Shing Leow,
Hee Hwa Ho,
Siu Kwan Sze
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Scientific Reports
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8 Jan 2020
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BMRC
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Singapore Institute for Clinical Sciences
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Fibroblast Growth Factor-21, Leptin, and Adiponectin Responses to Acute Cold-Induced Brown Adipose Tissue Activation
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Lijuan Sun,
Jianhua Yan,
Hui Jen Goh,
Priya Govindharajulu,
Sanjay Verma,
Navin Michael,
Suresh Anand Sadananthan,
Christiani Jeyakumar Henry,
S. Sendhil Velan,
Melvin Khee-Shing Leow
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Journal of Clinical Endocrinology & Metabolism
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|
3 Dec 2019
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BMRC
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Singapore Institute for Clinical Sciences
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Differential Effects of Monounsaturated and Polyunsaturated Fats on Satiety and Gut Hormone Responses in Healthy Subjects
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Lijuan Sun,
Hui Jen Goh,
Priya Govindharajulu,
Melvin Khee-Shing Leow,
Christiani Jeyakumar Henry
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Foods
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|
13 Jul 2019
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BMRC
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Singapore Institute for Clinical Sciences
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Brown Adipose Tissue: Multimodality Evaluation by PET, MRI, Infrared Thermography, and Whole-Body Calorimetry (TACTICAL-II)
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Sanjay Verma,
Navin Michael,
Lijuan Sun,
Siew Pang Chan,
Jianhua Yan,
Suresh Anand Sadananthan,
Stefan G. Camps,
Hui Jen Goh,
Priya Govindharajulu,
John Totman,
David Townsend,
Julian Pak-Nam Goh,
Lei Sun,
Bernhard Otto Boehm,
Su Chi Lim,
Siew Kwan Sze,
Christiani Jeyakumar Henry,
Houchun Harry Hu,
S. Sendhil Velan,
Melvin Khee-Shing Leow
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Obesity
|
|
13 Jun 2019
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BMRC
|
Singapore Institute for Clinical Sciences
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Can the Sequence of Food Presentation Influence Postprandial Glycaemia?
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Christiani Henry,
Lijuan Sun,
Priya Govindharajulu,
Melvin Khee-Shing Leow
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Current Developments in Nutrition
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|
27 Apr 2019
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BMRC
|
Singapore Institute for Clinical Sciences
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Postprandial Glucose, Insulin and Incretin Responses Differ by Test Meal Macronutrient Ingestion Sequence (PATTERN Study)
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Lijuan Sun,
Hui Jen Goh,
Priya Govindharajulu,
Melvin Khee-Shing Leow,
Christiani Jeyakumar Henry
|
Clinical Nutrition
|
|
19 Mar 2019
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BMRC
|
Singapore Institute for Clinical Sciences
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Associations of physical activity levels and screen time with oral glucose tolerance test profiles in Singaporean women of reproductive age actively trying to conceive: the S-PRESTO study
|
Jonathan Y. Bernard,
Sharon Ng,
Padmapriya Natarajan,
See Ling Loy,
Izzuddin M. Aris,
Mya Thway Tint,
Yap-Seng Chong,
Lynette Shek,
Jerry Chan,
Keith M. Godfrey,
Chin Meng Khoo,
Melvin Khee-Shing Leow,
Falk Müller-Riemenschneider,
Shiao-Yng Chan
|
Diabetic Medicine
|
|
1 Feb 2019
|
BMRC
|
Singapore Institute for Clinical Sciences
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Association Between Early Life Weight Gain and Abdominal Fat Partitioning at 4.5 Years is Sex, Ethnicity, and Age Dependent
|
Suresh Anand Sadananthan,
Mya Thway Tint,
Navin Michael,
Izzuddin M. Aris,
See Ling Loy,
Kuan Jin Lee,
Lynette Pei-chi Shek,
Fabian Kok Peng Yap,
Kok Hian Tan,
Keith M. Godfrey,
Melvin Khee-Shing Leow,
Yung Seng Lee,
Michael S. Kramer,
Peter D. Gluckman,
Yap Seng Chong,
Neerja Karnani,
Christiani Jeyakumar Henry,
Marielle Valerie Fortier,
S. Sendhil Velan
|
Obesity
|
|
21 Aug 2018
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BMRC
|
Singapore Institute for Clinical Sciences
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Ethnicity-specific skeletal muscle transcriptional signatures and their relevance to insulin resistance in Singapore
|
Amelia Li Min Tan,
Sarah R. Langley,
Chee Fan Tan,
Jin Fang Chai,
Chin Meng Khoo,
Melvin Khee-Shing Leow,
Eric Yin Hao Khoo,
Aida Moreno-Moral,
Michal Pravenec,
Maxime Rotival,
Suresh Anand Sadananthan,
S. Sendhil Velan,
Kavita Venkataraman,
Yap Seng Chong,
Yung Seng Lee,
Xueling Sim,
Walter Stunkel,
Mei Hui Liu,
E. Shyong Tai,
Enrico Petretto
|
Journal of Clinical Endocrinology & Metabolism
|
|
6 Apr 2018
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BMRC
|
Singapore Institute for Clinical Sciences
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De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis
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Chunming Ding,
Yen Ching Lim,
Sook Yoong Chia,
Arcinas Camille Esther Walet,
Shaohai Xu,
Kinyui Alice LO,
Yanling Zhao,
Dewen Zhu,
Zhihui Shan,
Qingfeng Chen,
Melvin Khee-Shing Leow,
Dan Xu,
Lei Sun
|
Nature Communications
|
|
6 Apr 2018
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BMRC
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Institute of Molecular and Cell Biology
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De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis
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Chunming Ding,
Yen Ching Lim,
Sook Yoong Chia,
Dan Xu,
Arcinas Camille Esther Walet,
Shaohai Xu,
Kinyui Alice LO,
Yanling Zhao,
Dewen Zhu,
Zhihui Shan,
Qingfeng Chen,
Melvin Khee-Shing Leow,
Lei Sun
|
Nature Communications
|
|
26 Jan 2018
|
BMRC
|
Singapore Institute for Clinical Sciences
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Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan
|
Lijuan Sun,
Stefan G. Camps,
Hui Jen Goh,
Priya Govindharajulu,
Joshua D. Schaefferkoetter,
David W. Townsend,
Sanjay K. Verma,
S. Sendhil Velan,
Lei Sun,
Siu Kwan Sze,
Su Chi Lim,
Bernhard Otto Boehm,
Christiani Jeyakumar Henry,
Melvin Khee-Shing Leow
|
American Journal of Clinical Nutrition
|
|
2 Oct 2017
|
BMRC
|
Institute of Molecular and Cell Biology
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RNA Binding Protein Ybx2 Regulates RNA Stability During Cold-Induced Brown Fat Activation
|
Dan Xu,
Shaohai Xu,
Aung Maung Maung Kyaw,
Yen Ching Lim,
Sook Yoong Chia,
Diana Teh Chee Siang,
Juan R. Alvarez-Dominguez,
Peng Chen,
Melvin Khee-Shing Leow,
Lei Sun
|
Diabetes
|
|
15 Jun 2017
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BMRC
|
Singapore Institute for Clinical Sciences
|
Characterization of the Asian Phenotype - An Emerging Paradigm with Clinicopathological and Human Research Implications
|
Melvin Khee-Shing Leow
|
International Journal of Medical Sciences
|
|
21 Jul 2016
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BMRC
|
Singapore Institute for Clinical Sciences
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A new method of infrared thermography for quantification of brown adipose tissue activation in healthy adults (TACTICAL): a randomized trial
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Qi Yan Ang,
Hui Jen Goh,
Yanpeng Cao,
Yiqun Li,
Siew-Pang Chan,
Judith L. Swain,
Christiani Jeyakumar Henry,
Melvin Khee-Shing Leow
|
Journal of Physiological Sciences
|
|
14 Jun 2016
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BMRC
|
Singapore Institute for Clinical Sciences
|
A Review of the Phenomenon of Hysteresis in the Hypothalamus-Pituitary-Thyroid Axis
|
Melvin Khee-Shing Leow
|
Frontiers in Endocrinology
|
|
1 Apr 2016
|
BMRC
|
Singapore Institute for Clinical Sciences
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Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice
|
Kenji Ohba,
Melvin Khee-Shing Leow,
Brijesh Kumar Singh,
Rohit Anthony Sinha,
Ronny Lesmana,
Xiao-Hui Liao,
Sujoy Ghosh,
Samuel Refetoff,
Judy Chia Ghee Sng,
Paul Michael Yen
|
Endocrinology
|
|
1 Nov 2015
|
BMRC
|
Singapore Institute for Clinical Sciences
|
Ethnic Differences in the Role of Adipocytokines Linking Abdominal Adiposity and Insulin Sensitivity Among Asians
|
Ehsan Parvaresh Rizi,
Yvonne Teo,
Melvin Khee-Shing Leow,
Eric Yin Hao Khoo,
Chia Rou Yeo,
Edmund Chan,
Tammy Song,
Suresh Anand Sadananthan,
S. Sendhil Velan,
Peter D. Gluckman,
Yung Seng Lee,
Yap Seng Chong,
E. Shyong Tai,
Sue-Anne Toh,
Chin Meng Khoo
|
Journal of Clinical Endocrinology & Metabolism
|
|
6 May 2015
|
BMRC
|
Singapore Institute for Clinical Sciences
|
Smartphone apps for calculating insulin dose: a systematic assessment
|
Kit Huckvale,
Samanta Adomaviciute,
José Tomás Prieto,
Melvin Khee-Shing Leow,
Josip Car
|
BMC Medicine
|
|
6 May 2015
|
BMRC
|
Singapore Institute for Clinical Sciences
|
Smartphone apps for calculating insulin dose: a systematic assessment
|
Kit Huckvale,
Samanta Adomaviciute,
José Tomás Prieto,
Melvin Khee-Shing Leow,
Josip Car
|
BMC Medicine
|
|
2 Oct 2014
|
BMRC
|
Singapore Institute for Clinical Sciences
|
Ethnic differences translate to inadequacy of high-risk screening for gestational diabetes mellitus in an Asian population: a cohort study
|
Yap-Seng Chong,
Shirong Cai,
Harvard Lin,
Shu E Soh,
Yung-Seng Lee,
Melvin Khee-Shing Leow,
Yiong-Huak Chan,
Li Chen,
Joanna D. Holbrook,
Kok-Hian Tan,
Victor Samuel Rajadurai,
George Seow-Heong Yeo,
Michael S. Kramer,
Seang-Mei Saw,
Peter D. Gluckman,
Keith M. Godfrey,
Kenneth Kwek
|
BMC Pregnancy Childbirth
|
|
8 Aug 2014
|
BMRC
|
Singapore Institute for Clinical Sciences
|
The homeostatic set point of the hypothalamus-pituitary-thyroid axis--maximum curvature theory for personalized euthyroid targets
|
Melvin Khee-Shing Leow,
Simon L. Goede
|
Theoretical Biology and Medical Modelling
|
|
7 May 2014
|
BMRC
|
Singapore Institute for Clinical Sciences
|
Automated segmentation of visceral and subcutaneous (deep and superficial) adipose tissues in normal and overweight men
|
Suresh Anand Sadananthan,
Bhanu Prakash,
Melvin Khee-Shing Leow,
Chin Meng Khoo,
Hong Chou,
Kavita Venkataraman,
Eric Y. H. Khoo,
Yung Seng Lee,
Peter D. Gluckman,
E. Shyong Tai,
S. Sendhil Velan
|
Journal of Magnetic Resonance Imaging
|
|
20 Dec 2013
|
BMRC
|
Singapore Institute for Clinical Sciences
|
Apelin attenuates oxidative stress in human adipocytes
|
Aung Than,
Xiaohong Zhang,
Melvin Khee-Shing Leow,
Chueh Loo Poh,
Seow Khoon Chong,
Peng Chen
|
Journal of Biological Chemistry
|
|
18 Dec 2013
|
BMRC
|
Singapore Institute for Clinical Sciences
|
Body fat partitioning does not explain the interethnic variation in insulin sensitivity among Asian ethnicity: the Singapore adults metabolism study
|
Chin Meng Khoo,
Melvin Khee-Shing Leow,
Suresh Anand Sadananthan,
Radiance Lim,
Kavita Venkataraman,
Eric Yin Hao Khoo,
S. Sendhil Velan,
Yu Ting Ong,
Ravi Kambadur,
Craig McFarlane,
Peter D. Gluckman,
Yung Seng Lee,
Yap Seng Chong,
E. Shyong Tai
|
Diabetes
|
|
27 Jun 2013
|
BMRC
|
Singapore Institute for Clinical Sciences
|
Determinants of Health-Related Quality of Life (HRQoL) in the Multiethnic Singapore Population – A National Cohort Study
|
Melvin Khee-Shing Leow,
Konstadina Griva,
Robin Choo,
Hwee-Lin Wee,
Julian Thumboo,
E. Shyong Tai,
Stanton Newman
|
PLoS One
|
|
16 Apr 2013
|
BMRC
|
Singapore Institute for Clinical Sciences
|
Control of Adipogenesis by the Autocrine Interplays Between Angiotensin 1-7/Mas Receptor and Angiotensin II/AT1 Receptor Signaling Pathways
|
Aung Than,
Melvin Khee-Shing Leow,
Peng Chen
|
Journal of Biological Chemistry
|