This is the peer reviewed version of the following article: Lama, D, Verma, CS. Deciphering the mechanistic effects of eIF4E phosphorylation on mRNA‐cap recognition. Protein Science. 2019; 1– 14. https://doi.org/10.1002/pro.3798, which has been published in final form at https://doi.org/10.1002/pro.3798. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.