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11 May 2020 BMRC Bioinformatics Institute Macrocyclization of an all-D linear α-helical peptide imparts cellular permeability Srinivasaraghavan Kannan, Pietro G. A. Aronica, Simon Ng, Dawn Thean Gek Lian, Yuri Frosi, Sharon Chee, Shimin Jiang, Tsz Ying Yuen, Ahmad Sadruddin, Hung Yi Kristal Kaan, Arun Chandramohan, Yi Han, Jin Huei Wong, Yaw Sing Tan, Zi Wei Chang, Fernando Jose Ferrer-Gago, Prakash Arumugam, Shiying Chen, Laurent Claude Stephane Renia, Christopher J. Brown, Charles W. Johannes, Brian Henry, David P. Lane, Tomi K Sawyer, Chandra S. Verma, Anthony William Patridge Chemical Science
10 May 2020 BMRC Bioinformatics Institute Extending the Martini coarse-grained forcefield to N-glycans Aishwary T. Shivgan, Jan K. Marzinek, Roland G. Huber, Alexander Krah, Richard H. Henchman, Paul Matsudaira, Chandra S. Verma, Peter J. Bond bioRxiv
5 May 2020 BMRC Bioinformatics Institute De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits Simon Ng, Yu-Chi Juang, Arun Chandramohan, Hung Yi Kristal Kaan, Ahmad Sadruddin, Tsz Ying Yuen, Fernando J. Ferrer-Gago, Xue'Er Cheryl Lee, Liew Xi, Charles W. Johanes, Christopher J. Brown, Srinivasaraghavan Kanan, Pietro G. Aronica, Nils A. Berglund, Chandra S. Verma, Lijuan Liu, Alexander Stoeck, Tomi K. Sawyer, Anthony W. Partridge, David P. Lane ACS Medicinal Chemistry Letters
29 Apr 2020 BMRC Bioinformatics Institute Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation Li Ren Kong, Richard Weijie Ong, Tua Zea Tan, Nur Afiqah Binte Mohamed Salleh, Matan Thangavelu, Jane Vin Chan, Lie Yong Judice Koh, Giridharan Periyasamy, Jieying Amelia Lau, Thi Bich Uyen Le, Lingzhi Wang, Miyoung Lee, Srinivasaraghavan Kannan, Chandra S. Verma, Chwee Ming Lim, Wee Joo Chng, David P. Lane, Ashok Venkitaraman, Huynh The Hung, Chit Fang Cheok, Boon Cher Goh Nature Communications
24 Apr 2020 BMRC Bioinformatics Institute Mechanism of polyamine induced colistin resistance through electrostatic networks on bacterial outer membranes Jianguo Li, Roger Beuerman, Chandra S. Verma Biochimica et Biophysica Acta (BBA) - Biomembranes
25 Mar 2020 BMRC Bioinformatics Institute A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma Nur Afiqah Binte Mohamed Salleh, Richard Weijie Ong, Li Ren Kong, Tuan Zea Tan, Nicholas L. Syn, Robby Miguel Goh, Chee Wai Fhu, Daniel S W Tan, Gopalakrishna Iyer, Srinivasaraghavan Kannan, Chandra S. Verma, Yaw Chyn Lim, Ross Soo, Jingshan Ho, Yiqing Huang, Joline S. J. Lim, Benedict Junrong Yan, Min En Nga, Seng Gee Lim, H. Philip Koeffler, Soo Chin Lee, Dennis Kappei, Huyhn The Hung, Boon Cher Goh Nature Communications
10 Dec 2019 BMRC Bioinformatics Institute Quantum scale biomimicry of low dimensional growth: An unusual complex amorphous precursor route to TiO2 band confinement by shape adaptive biopolymer-like flexibility for energy applications Dahyun Choi, Sanjiv Sonkaria, Stephen J. Fox, Shivraj Poudel, Sung-yong Kim, Suhee Kang, Seheon Kim, Chandra S. Verma, Sung Hoon Ahn, Caroline Sunyong Lee, Varsha Khare Scientific Reports
6 Dec 2019 BMRC Bioinformatics Institute Deciphering the mechanistic effects of eIF4E phosphorylation on mRNA‐cap recognition Dilraj Lama, Chandra S. Verma Protein Science
28 Nov 2019 BMRC Bioinformatics Institute The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors Srinivasaraghavan Kannan, Anthony W. Partridge, David P. Lane, Chandra S. Verma International Journal of Molecular Sciences
11 Nov 2019 BMRC Bioinformatics Institute Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1 Umesh Kalathiya, Monikaben Padariya, Kamila Pawlicka, Chandra S. Verma, Douglas Houston, Ted R. Hupp, Javier Antonio Alfaro International Journal of Molecular Sciences
19 Sep 2019 BMRC Bioinformatics Institute Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C Xin-Ni Lim, Chao Shan, Jan K. Marzinek, Hongping Dong, Thiam Seng Ng, Justing S. G. Ooi, Guntur Fibrianshah, Jiaqi Wang, Chandra S. Verma, Peter J. Bond, Pei-Yong Shi, Shee-Mei Lok PLOS Pathogens
9 Sep 2019 BMRC Bioinformatics Institute Three-dimensional structure of Megabalanus rosa Cement Protein 20 revealed by multi-dimensional NMR and molecular dynamics simulations Harini Mohanram, Akshita Kumar, Chandra S. Verma, Konstantin Pervushin, Ali Miserez Philosophical Transactions B: Biological Sciences
19 Aug 2019 BMRC Bioinformatics Institute Development and application of a transcriptional sensor for detection of heterologous acrylic acid production in E. coli Sarada S. Raghavan, Sharon Chee, Juntao Li, Jeremie Poschmann, Niranjan Nagarajan, Siau Jia Wei, Chandra S. Verma, Farid Ghadessy Microbial Cell Factories
9 Jul 2019 BMRC Bioinformatics Institute A Novel Determinant of PSMD9 PDZ Binding Guides the Evolution of the First Generation of Super Binding Peptides Mohan R. Pradhan, Chandra S. Verma, Mahalakshmi Harish, Srinivasaraghavan Kannan, Srivalli Puttagunta, Prasanna Venkatraman Biochemistry
20 Jun 2019 BMRC Bioinformatics Institute Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties Anthony W. Patridge, Hung Yi Kristal Kaan, Yu-Chi Juang, Ahmad Sadruddin, Shuhui Lim, Christopher J. Brown, Simon Ng, Dawn Thean, Fernando Ferrer, Charles Johannes, Tsz Ying Yuen, Srinivasaraghavan Kannan, Pietro Aronica, Yaw Sing Tan, Mohan R. Praddhan, Chandra S. Verma, Jerome Hochman, Shiying Chen, Hui Wan, Sookhee Ha, Brad Sherbone, David P. Lane, Tomi K. Sawyer Molecules
17 Jun 2019 BMRC Bioinformatics Institute Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides Jiraborrirak Charoenpattarapreeda, Yaw Sing Tan, Jessica Iegre, Stephen J. Walsh, Elaine Fowler, Rohan Eapen, Yuteng Wu, Hannah F. Sore, Chandra S. Verma, Laura Itzhaki, David R. Spring Chemical Communications
30 May 2019 BMRC Bioinformatics Institute Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles A. Johannes Chemical Science
30 May 2019 BMRC p53 Laboratory Stereoisomerism of Stapled Peptide Inhibitors of the p53-Mdm2 Interaction: An Assessment of Synthetic Strategies and Activity Profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles W. Johannes Chemical Science
30 May 2019 SERC Institute of Chemical and Engineering Sciences Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles W. Johannes Chemical Science
29 May 2019 BMRC Bioinformatics Institute Characterization of Hydration Properties in Structural Ensembles of Biomolecules Mohan R. Pradhan, Minh N. Nguyen, Srinivasaraghavan Kannan, Stephen J. Fox, Chee Keong Kwoh, David P. Lane, Chandra S. Verma Journal of Chemical Information and Modeling
28 May 2019 BMRC Bioinformatics Institute Preclinical Characteristics of the Irreversible Pan-HER Kinase Inhibitor Neratinib Compared with Lapatinib: Implications for the Treatment of HER2-Positive and HER2-Mutated Breast Cancer Denis M. Collins, Neil T. Conlon, Srinivasaraghavan Kannan, Chandra S. Verma, Lisa D. Eli, Alshad S. Lalani, John Crown Cancers
17 May 2019 BMRC Bioinformatics Institute Exploring Gatekeeper Mutations in EGFR through Computer Simulations Srinivasaraghavan Kannan, Stephen J. Fox, Chandra S. Verma Journal of Chemical Information and Modeling
9 May 2019 BMRC Bioinformatics Institute AppA: a web server for analysis, comparison, and visualization of contact residues and interfacial waters of antibody–antigen structures and models Minh N. Nguyen, Chandra S. Verma, Pingyu Zhong Nucleic Acids Research
29 Apr 2019 BMRC p53 Laboratory p53: Updates on Mechanisms, Biology and Therapy (II) David P. Lane, Chandra S. Verma Journal of Molecular Cell Biology
23 Apr 2019 BMRC p53 Laboratory p53: Updates on Mechanisms, Biology and Therapy (I) David P. Lane, Chandra S. Verma Journal of Molecular Cell Biology
9 Apr 2019 BMRC Bioinformatics Institute Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction† Jessica Iegre, Paul Brear, David J. Baker, Yaw Sing Tan, Eleanor L. Atkinson, Hannah F. Sore, Daniel H. O' Donovan, Chandra S. Verma, Marko Hyvonen, David R. Spring Chemical Science
14 Mar 2019 BMRC Bioinformatics Institute Inhibiting S100B(ββ) for Activating Wild-Type p53: Design of Stapled Peptides Kannan Srinivasaraghavan, Pietro G. A. Aronica, Yaw Sing Tan, Chandra S. Verma ACS Omega
9 Mar 2019 BMRC Bioinformatics Institute An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin Dominika Coufalova, Lucy Remnant, Lenka Hernychova, Petr Muller, Alan Healy, Srinivasaraghavan Kannan, Nicholas Westwood, Chandra S. Verma, Borek Vojtesek, Ted R. Hupp, Douglas R. Houston Journal of Proteomics
22 Feb 2019 BMRC Bioinformatics Institute Discovering Putative Protein Targets of Small Molecules: A Study of the p53 Activator Nutlin Minh N. Nguyen, Neeladri Sen, Meiyin LIn, Thomas Leonard Joseph, Candida Vaz, Vivek Tanavde, Luke Way, Ted Hupp, Chandra S. Verma, M. S. Madhusudhan Journal of Chemical Information and Modeling
6 Feb 2019 BMRC Bioinformatics Institute Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting Yaw Sing Tan, Yasmina Mhoumadi, Chandra S. Verma Journal of Molecular Cell Biology
24 Jan 2019 BMRC Bioinformatics Institute Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2 Shilpa Yadahalli, Jose L. Neira, Christopher M. Johnson, Yaw Sing Tan, Pamela J. E. Rowling, Anasuya Chattopadhyay, Chandra S. Verma, Laura S. Itzhaki Scientific Reports
15 Jan 2019 BMRC Bioinformatics Institute Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket Mohan R. Pradhan, Jia Wei Siau, Srinivasaraghavan Kannan, Minh N. Nguyen, Zohra Ouaray, Chee Keong Kwoh, David P. Lane, Farid Ghadessy, Chandra S. Verma Nucleic Acids Research
21 Nov 2018 BMRC Bioinformatics Institute Mechanism of enhanced immature dengue virus attachment to endosomal membrane induced by prM antibody Melissa Wirawan, Guntur Fibriansah, Jan K. Marzinek, Xin Xiang Lim, Thiam Seng Ng, Adelene Y. L. Sim, Qian Zhang, Victor A. Kostyuchenko, Jian Shi, Scott A. Smith, Chandra S. Verma, Ganesh Anand, James E. Crowe Jr, Peter J. Bond, Shee-Mei Lok Structure
21 Nov 2018 BMRC Bioinformatics Institute Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody Melissa Wirawan, Guntur Fibriansah, Jan K. Marzinek, Xin Xiang Lim, Thiam-Seng Ng, Adelene Y. L. Sim, Qian Zhang, Victor A. Kostyuchenko, Jian Shi, Scott A. Smith, Chandra S. Verma, Ganesh Anand, James E. Jr Crowe, Peter J. Bond, Shee-Mei Lok Structure
12 Jul 2018 BMRC Bioinformatics Institute Homologous Lympho-Epithelial Kazal-type Inhibitor Domains Delay Blood Coagulation by Inhibiting Factor X and XI with Differential Specificity Karthik Ramesh, Dilraj Lama, Kang Wei Tan, Van Sang Nguyen, Fook Tim Chew, Chandra S. Verma, Yu Keung Mok Structure
5 Jul 2018 BMRC Experimental Drug Development Centre Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide Bee Hui Liu, Chacko Jobichen, Cheng San Brian Chia, Tim Hon Man Chan, Jing Ping Tang, Theodora Chung, Jia Li, Anders Poulsen, Alvin W. Hung, Xiaoying Koh-Stenta, Yaw Sing Tan, Chandra S. Verma, Hong Kee Tan, Chan-shuo Wu, Feng Li, Jeffrey Hill, Joma Joy, Henry Yang, Li Chai, J. Sivaraman, Daniel G. Tenen PNAS
5 Jul 2018 BMRC Bioinformatics Institute Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide Bee Hui Liu, Chacko Jobichen, C. S. Brian Chia, Tim Hon Man Chan, Jing Ping Tang, Theodora X. Y. Chung, Jia Li, Anders Poulsen, Alvin W. Hung, Xiaoying Koh-Stenta, Yaw Sing Tan, Chandra S. Verma, Hong Kee Tan, Chan-shuo Wu, Feng Li, Jeffrey Hill, Joma Joy, Henry Yang, Li Chai, J. Sivaraman, Daniel G. Tenen Proceedings of the National Academy of Sciences
31 May 2018 BMRC Bioinformatics Institute Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513 Yee Hwa Wong, Akshita Kumar, Chong Wai Liew, Kannan Tharakaraman, Kannan Srinivasaraghavan, Ram Sasisekharan, Chandra S. Verma, Julien Lescar Scientic Reports
27 Apr 2018 BMRC Bioinformatics Institute Comparison of Charge Derivation Methods Applied to Amino Acid Parameterization Pietro G. A. Aronica, Stephen J. Fox, Chandra S. Verma ACS Omega
23 Apr 2018 BMRC Bioinformatics Institute Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia Haiyan Yang, Lohitha Rao Chennamaneni, Melvyn Wai Tuck Ho, Shi Hua Ang, Eldwin Sum Wai Tan, Duraiswamy Athisayamani Jeyaraj, Yoon Sheng Yeap, Boping Liu, Esther Hq Ong, Joma Kanikadu Joy, John Liang Kuan Wee, Perlyn Kwek, Priya Retna, Nurul Dinie, Thuy Thi Hanh Nguyen, Shi Jing Tai, Vithya Manoharan, Vishal Pendharkar, Choon Bing Low, Yun Shan Chew, Susmitha Vuddagiri, Kanda Sangthongpitag, Meng Ling Choong, May Ann Lee, Srinivasaraghavan Kannan, Chandra S. Verma, Anders Poulsen, Sharon Lim, Charles Chuah, Tiong Sin Ong, Jeffrey Hill, Alex Matter, Kassoum Nacro Journal of Medicinal Chemistry
1 Mar 2018 BMRC Bioinformatics Institute Molecular Insights into the Membrane Affinities of Model Hydrophobes Jianguo Li, Roger W. Beuerman, Chandra S. Verma ACS Omega
1 Feb 2018 BMRC Bioinformatics Institute Large scale ab initio modeling of structurally uncharacterized antimicrobial peptides reveals known and novel folds Daniel J. Rigden, Mara Kozic, Stephen J. Fox, Jens M. Thomas, Chandra S. Verma Proteins: Structure, Function, and Bioinformatics
8 Dec 2017 SERC Institute of Chemical and Engineering Sciences An intramolecular tryptophan-condensation approach for peptide stapling Yaw Sing Tan, Chandra S. Verma, Kok-Ping Chan, Charles W. Johannes, Eunice Y.-L. Hui, Bhimsen Rout Organic & Biomolecular Chemistry
1 Dec 2017 BMRC p53 Laboratory Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53 Jane Vin Chan, Dawn Xin Ping Koh, Yun Liu, Thomas L. Joseph, David P. Lane, Chandra S. Verma, Yaw Sing Tan Oncotarget
15 Nov 2017 BMRC p53 Laboratory Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations Shilpa Yadahalli, Jianguo Li, David P. Lane, Shachi Gosavi, Chandra S. Verma Scientific Reports
9 Nov 2017 BMRC p53 Laboratory A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53 Jin Huei Wong, Mohammad Alfatah, Mei Fang Sin, Hong May Sim, Chandra S. Verma, David P. Lane, Prakash Arumugam BMC Biology
14 Feb 2017 BMRC Bioinformatics Institute Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design Jianguo Li, Jun-Jie Koh, Shouping Liu, Rajamani Lakshminarayanan, Chandra S. Verma, Roger W. Beuerman Frontiers in Neuroscience
8 Feb 2017 BMRC Bioinformatics Institute Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it Wai-Heng Lua, Wei-Li Ling, Chinh Tran-To Su, Joshua Yi Yeo, Chandra S. Verma, Birgit Eisenhaber, Frank Eisenhaber, Samuel Ken-En Gan Cell Cycle
13 Jan 2017 BMRC Bioinformatics Institute Macrocyclized extended peptides: Inhibiting the substrate-recognition domain of tankyrase Yu Heng Lau, Gerhard Fischer, Yaw Sing Tan, Anasuya Chattopadhyay, Marc de la Roche, Marko Hyvonen, Chandra S. Verma, David R. Spring, Laura S. Itzhaki, Wenshu Xu Journal of the American Chemical Society
3 Jan 2017 BMRC Bioinformatics Institute Water-Bridge Mediates Recognition of mRNA Cap in eIF4E Dilraj Lama, Mohan R. Pradhan, Christopher J. Brown, Rohan S. Eapen, Thomas L. Joseph, Chee-Keong Kwoh, David P. Lane, Chandra S. Verma Structure