A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2

Page view(s)
66
Checked on Apr 06, 2025
A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2
Title:
A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2
Journal Title:
Journal of the American Chemical Society
Keywords:
Publication Date:
22 August 2019
Citation:
J. Am. Chem. Soc. 2019, 141, 37, 14673-14686
Abstract:
Tumor initiating cells (TIC) are resistant to conventional anticancer therapy and associated with metastasis and relapse in cancer. Although various TIC markers and their antibodies have been proposed, it is limited to the use of antibodies for in vivo imaging or treatment of TIC. In this study, we discovered heme oxygenase 2 (HMOX2) as a novel biomarker for TIC and developed a selective small molecule probe TiNIR (tumor initiating cell probe with near infrared). TiNIR detects and enriches the functionally active TIC in human lung tumors, and through the photoacoustic property, TiNIR also visualizes lung TIC in the patient-derived xenograft (PDX) model. Furthermore, we demonstrate that TiNIR inhibits tumor growth by blocking the function of HMOX2, resulting in significantly increased survival rates of the cancer model mice. The novel therapeutic target HMOX2 and its fluorescent ligand TiNIR will open a new path for the molecular level of lung TIC diagnosis and treatment.
License type:
PublisherCopyrights
Funding Info:
This work was supported by intramural funding from the Agency for Science, Technology and Research, Singapore (A*STAR) (core funding to W.L.T) Biomedical Research Council and the National Medical Research Council grant NMRC/TCR/016-NNI/2016, and Institute for Basic Science (IBS) IBS-R077-A1. Ex vivo images for this study were acquired at the SBICBruker Preclinical Imaging (PCI) Centre, Bruker Singapore (www.pci-lab.com).
Description:
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/jacs.9b06068
ISSN:
0002-7863
1520-5126
Files uploaded:

File Size Format Action
manuscript.pdf 2.47 MB PDF Open