Decarboxylative/Sonogashira-type cross-coupling using PdCl2(Cy*Phine)2

Decarboxylative/Sonogashira-type cross-coupling using PdCl2(Cy*Phine)2
Title:
Decarboxylative/Sonogashira-type cross-coupling using PdCl2(Cy*Phine)2
Other Titles:
RSC Advances
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Publication Date:
27 July 2016
Citation:
RSC Adv., 2016,6, 72810-72814
Abstract:
The PdCl2(Cy*Phine)2 precatalyst containing the meta-terarylphosphine ligand, Cy*Phine, can effectively mediate decarboxylative cross-coupling with a diverse range of (hetero-)aryl, aryl and alkyl chlorides including those with unprotected functionality. Using a facile and robust protocol, this process was extended to the first synthesis of symmetrical di(heteroaryl)alkynes via tandem Sonogashira/decarboxylative cross-coupling of heteroaryl chlorides and propiolic acid.
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PublisherCopyrights
Funding Info:
Financial support for this work was provided by the A*STAR Joint Council Office (JCO), the Singapore 1st JCO Developmental Programme (DP) (grant JCO 1230400020 to Y. H. L., E. R. and C. W. J.), the A*STAR Institute of Chemical and Engineering Sciences (ICES) and the A*STAR Singapore Bioimaging Consortium (SBIC).
Description:
ISSN:
2046-2069
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