Genetic instability is a hallmark of cancer cells, and occurs when genes required for genomic maintenance are inactivated. It emerges that altering just one of the two copies of certain genes can drive genetic instability in yeast.
This work was supported by an A*STAR Investigatorship awarded to G.R. (1437a00119).
The full paper is available for download at the publisher's URL: https://doi.org/10.1038/d41586-019-00260-4