Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction

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Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction
Title:
Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction
Other Titles:
JACC: Basic to Translational Science
Publication Date:
30 May 2018
Citation:
Leonardo P. de Carvalho, Sock Hwee Tan, Ghim-Siong Ow, Zhiqun Tang, Jianhong Ching, Jean-Paul Kovalik, Sock Cheng Poh, Chee-Tang Chin, A. Mark Richards, Eliana C. Martinez, Richard W. Troughton, Alan Yean-Yip Fong, Bryan P. Yan, Aruni Seneviratna, Vitaly Sorokin, Scott A. Summers, Vladimir A. Kuznetsov, Mark Y. Chan, Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction, JACC: Basic to Translational Science, Volume 3, Issue 2, 2018, Pages 163-175, ISSN 2452-302X, https://doi.org/10.1016/j.jacbts.2017.12.005.
Abstract:
We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.
License type:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Funding Info:
Description:
ISSN:
2452-302X
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