Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction

Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction

JACC: Basic to Translational Science

10.1016/j.jacbts.2017.12.005

https://doi.org/10.1016/j.jacbts.2017.12.005

Leonardo P. de Carvalho, Sock Hwee Tan, Ghim-Siong Ow, Zhiqun Tang, Jianhong Ching, Jean-Paul Kovalik, Sock Cheng Poh, Chee-Tang Chin, Mark Richards, Eliana C. Martinez, Richard W. Troughton, Alan Yean-Yip Fong, Bryan P. Yan, Aruni Seneviratna, Vitaly Sorokin, Scott A. Summers, Vladimir A. Kuznetsov, Mark Y. Chan

acute coronary syndrome, ceramides, dihydroceramides, major adverse cardiovascular and cerebrovascular events, prognosis, risk prediction

30 May 2018

Leonardo P. de Carvalho, Sock Hwee Tan, Ghim-Siong Ow, Zhiqun Tang, Jianhong Ching, Jean-Paul Kovalik, Sock Cheng Poh, Chee-Tang Chin, A. Mark Richards, Eliana C. Martinez, Richard W. Troughton, Alan Yean-Yip Fong, Bryan P. Yan, Aruni Seneviratna, Vitaly Sorokin, Scott A. Summers, Vladimir A. Kuznetsov, Mark Y. Chan, Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction, JACC: Basic to Translational Science, Volume 3, Issue 2, 2018, Pages 163-175, ISSN 2452-302X, https://doi.org/10.1016/j.jacbts.2017.12.005.

We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.

http://creativecommons.org/licenses/by-nc-nd/4.0/

https://oar.a-star.edu.sg/communities-collections/articles/14720

2452-302X

Bioinformatics Institute