Hui, E. Y. L.; Rout, B.; Tan, Y. S.; Verma, C. S.; Chan, K. P.; Johannes, C. W., An intramolecular tryptophan-condensation approach for peptide stapling. Organic & Biomolecular Chemistry 2018, 16 (3), 389-392
Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein–protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at the C2 position of the indole moieties via acid-mediated condensation with an aldehyde.
This work was funded by the A*STAR Joint Council Office (JCO) [1231BFG036].