An intramolecular tryptophan-condensation approach for peptide stapling

An intramolecular tryptophan-condensation approach for peptide stapling
Title:
An intramolecular tryptophan-condensation approach for peptide stapling
Other Titles:
Organic & Biomolecular Chemistry
Keywords:
Publication Date:
08 December 2017
Citation:
Hui, E. Y. L.; Rout, B.; Tan, Y. S.; Verma, C. S.; Chan, K. P.; Johannes, C. W., An intramolecular tryptophan-condensation approach for peptide stapling. Organic & Biomolecular Chemistry 2018, 16 (3), 389-392
Abstract:
Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein–protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at the C2 position of the indole moieties via acid-mediated condensation with an aldehyde.
License type:
PublisherCopyrights
Funding Info:
This work was funded by the A*STAR Joint Council Office (JCO) [1231BFG036].
Description:
ISSN:
1477-0520
1477-0539
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