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18 Aug 2020 BMRC Bioinformatics Institute Straightforward incorporation of multiple ligand types into molecular dynamics simulations for efficient binding site detection and characterization Yaw Sing Tan, Chandra S Verma
11 May 2020 BMRC Bioinformatics Institute Macrocyclization of an all-D linear α-helical peptide imparts cellular permeability Srinivasaraghavan Kannan, Pietro G. A. Aronica, Simon Ng, Dawn Thean Gek Lian, Yuri Frosi, Sharon Chee, Shimin Jiang, Tsz Ying Yuen, Ahmad Sadruddin, Hung Yi Kristal Kaan, Arun Chandramohan, Yi Han, Jin Huei Wong, Yaw Sing Tan, Zi Wei Chang, Fernando Jose Ferrer-Gago, Prakash Arumugam, Shiying Chen, Laurent Claude Stephane Renia, Christopher J. Brown, Charles W. Johannes, Brian Henry, David P. Lane, Tomi K Sawyer, Chandra S. Verma, Anthony William Patridge
11 Dec 2019 SERC Institute of Chemical and Engineering Sciences Synthesis of chiral alkenyl cyclopropane amino acids for incorporation into stapled peptides Tsz Ying Yuen, Christopher J. Brown, Yaw Sing Tan, Charles W. Johannes
20 Jun 2019 BMRC Bioinformatics Institute Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties Anthony W. Patridge, Hung Yi Kristal Kaan, Yu-Chi Juang, Ahmad Sadruddin, Shuhui Lim, Christopher J. Brown, Simon Ng, Dawn Thean, Fernando Ferrer, Charles Johannes, Tsz Ying Yuen, Srinivasaraghavan Kannan, Pietro Aronica, Yaw Sing Tan, Mohan R. Praddhan, Chandra S. Verma, Jerome Hochman, Shiying Chen, Hui Wan, Sookhee Ha, Brad Sherbone, David P. Lane, Tomi K. Sawyer
17 Jun 2019 BMRC Bioinformatics Institute Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides Jiraborrirak Charoenpattarapreeda, Yaw Sing Tan, Jessica Iegre, Stephen J. Walsh, Elaine Fowler, Rohan Eapen, Yuteng Wu, Hannah F. Sore, Chandra S. Verma, Laura Itzhaki, David R. Spring
30 May 2019 BMRC Bioinformatics Institute Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles A. Johannes
30 May 2019 BMRC p53 Laboratory Stereoisomerism of Stapled Peptide Inhibitors of the p53-Mdm2 Interaction: An Assessment of Synthetic Strategies and Activity Profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles W. Johannes
30 May 2019 SERC Institute of Chemical and Engineering Sciences Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles W. Johannes
9 Apr 2019 BMRC Bioinformatics Institute Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction† Jessica Iegre, Paul Brear, David J. Baker, Yaw Sing Tan, Eleanor L. Atkinson, Hannah F. Sore, Daniel H. O' Donovan, Chandra S. Verma, Marko Hyvonen, David R. Spring
14 Mar 2019 BMRC Bioinformatics Institute Inhibiting S100B(ββ) for Activating Wild-Type p53: Design of Stapled Peptides Kannan Srinivasaraghavan, Pietro G. A. Aronica, Yaw Sing Tan, Chandra S. Verma
6 Feb 2019 BMRC Bioinformatics Institute Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting Yaw Sing Tan, Yasmina Mhoumadi, Chandra S. Verma
24 Jan 2019 BMRC Bioinformatics Institute Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2 Shilpa Yadahalli, Jose L. Neira, Christopher M. Johnson, Yaw Sing Tan, Pamela J. E. Rowling, Anasuya Chattopadhyay, Chandra S. Verma, Laura S. Itzhaki
5 Jul 2018 BMRC Experimental Drug Development Centre Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide Bee Hui Liu, Chacko Jobichen, Cheng San Brian Chia, Tim Hon Man Chan, Jing Ping Tang, Theodora Chung, Jia Li, Anders Poulsen, Alvin W. Hung, Xiaoying Koh-Stenta, Yaw Sing Tan, Chandra S. Verma, Hong Kee Tan, Chan-shuo Wu, Feng Li, Jeffrey Hill, Joma Joy, Henry Yang, Li Chai, J. Sivaraman, Daniel G. Tenen
5 Jul 2018 BMRC Bioinformatics Institute Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide Bee Hui Liu, Chacko Jobichen, C. S. Brian Chia, Tim Hon Man Chan, Jing Ping Tang, Theodora X. Y. Chung, Jia Li, Anders Poulsen, Alvin W. Hung, Xiaoying Koh-Stenta, Yaw Sing Tan, Chandra S. Verma, Hong Kee Tan, Chan-shuo Wu, Feng Li, Jeffrey Hill, Joma Joy, Henry Yang, Li Chai, J. Sivaraman, Daniel G. Tenen
25 Apr 2018 BMRC Bioinformatics Institute Stapled peptides as a new technology to investigate protein-protein interactions in human platelets Jessica Iegre, Niaz S. Ahmed, Josephine S. Gaynord, Yuteng Wu, Kara M. Herlihy, Yaw Sing Tan, Maria E. Lopes-Pires, Rupam Jha, Yu Heng Lau, Hannah F. Sore, Chandra Verma, Daniel H. O' Donovan, Nicholas Pugh, David R. Spring
25 Apr 2018 BMRC Bioinformatics Institute Stapled peptides as a new technology to investigate protein-protein interactions in human platelets Jessica Legre, Niaz S. Ahmed, Josephine S. Gaynord, Yuteng Wu, Kara M. Herlihy, Yaw Sing Tan, Maria E. Lopes-Pires, Rupam Jha, Yu Heng Lau, Hannah F. Sore, Chandra Verma, Daniel H. O'Donovan, Nicholas Pugh, David R. Spring
8 Dec 2017 SERC Institute of Chemical and Engineering Sciences An intramolecular tryptophan-condensation approach for peptide stapling Yaw Sing Tan, Chandra S. Verma, Kok-Ping Chan, Charles W. Johannes, Eunice Y.-L. Hui, Bhimsen Rout
1 Dec 2017 BMRC p53 Laboratory Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53 Jane Vin Chan, Dawn Xin Ping Koh, Yun Liu, Thomas L. Joseph, David P. Lane, Chandra S. Verma, Yaw Sing Tan
7 Feb 2017 BMRC p53 Laboratory Anatomy of Mdm2 and Mdm4 in evolution Ban Xiong Tan, Hoe Peng Liew, Joy S. Chua, Farid J. Ghadessy, Yaw Sing Tan, David P. Lane, Cynthia R. Coffill
13 Jan 2017 BMRC Bioinformatics Institute Macrocyclized extended peptides: Inhibiting the substrate-recognition domain of tankyrase Yu Heng Lau, Gerhard Fischer, Yaw Sing Tan, Anasuya Chattopadhyay, Marc de la Roche, Marko Hyvonen, Chandra S. Verma, David R. Spring, Laura S. Itzhaki, Wenshu Xu
5 Dec 2016 BMRC Bioinformatics Institute Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer Mareike M. Wiedmann, Yaw Sing Tan, Yuteng Wu, Shintaro Aibara, Wenshu Xu, Hannah F. Sore, Chandra S. Verma, Laura Itzhaki, Murray Stewart, James D. Brenton, David R. Spring
28 Sep 2016 BMRC Bioinformatics Institute Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens Jia Wei Siau, Cynthia R. Coffill, Weiyun Villien Zhang, Yaw Sing Tan, Juliane Hundt, David Lane, Chandra Verma, Farid Ghadessy
17 Aug 2016 BMRC Bioinformatics Institute Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design Yaw Sing Tan, Judith Reeks, Christopher J. Brown, Dawn Thean, Fernando Jose Ferrer Gago, Tsz Ying Yuen, Eunice Tze Leng Goh, Xue Er Cheryl Lee, Claire E. Jennings, Thomas L. Joseph, Rajamani Lakshminarayanan, David P. Lane, Martin E. M. Noble, Chandra S. Verma
11 Jul 2016 BMRC Bioinformatics Institute Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells Bernardas Morkunas, Balint Gal, Warren R J D Galloway, James T Hodgkinson, Brett M Ibbeson, Yaw Sing Tan, Martin Welch, David R Spring
21 Jan 2016 BMRC Bioinformatics Institute The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans Cynthia R. Coffill, Alison P. Lee, Jia Wei Siau, Sharon M. Chee, Thomas L. Joseph, Yaw Sing Tan, Arumugam Madhumalar, Boon-Hui Tay, Sydney Brenner, Chandra S. Verma, Farid J. Ghadessy, Byrappa Venkatesh, David P. Lane