Validity of a new optic disc grading software for use in clinical and epidemiological research

Validity of a new optic disc grading software for use in clinical and epidemiological research

Clinical & Experimental Ophthalmology

10.1111/ceo.12112

http://dx.doi.org/10.1111/ceo.12112

Carol Yim Lui Cheung, Tien Yin Wong, Mani Baskaran, Jiang Liu, Beng Hai Lee, Fengshou Yin, Damon Wing Kee Wong, Jie Jin Wang, Paul Mitchell, Tin Aung, Ching Yu Cheng, Yih Chung Tham

bioimaging

25 April 2013

Tham, Y.-C., Cheung, C. Y., Wong, T. Y., Baskaran, M., Liu, J., Lee, B.-H., Yin, F., Wong, D. W., Wang, J. J., Mitchell, P., Aung, T. and Cheng, C.-Y. (2013), Validity of a new optic disc grading software for use in clinical and epidemiological research. Clinical & Experimental Ophthalmology, 41: 842–852. doi: 10.1111/ceo.12112

Background: To determine the reliability and agreement of a new optic disc grading software program for use in clinical, epidemiological research. Design: Reliability and agreement study. Samples: 328 monoscopic and 85 stereoscopic optic disc images. Methods: Optic disc parameters were measured using a new optic disc grading software (Singapore Optic Disc Assessment) that is based on polynomial curve-fitting algorithm. Two graders independently graded 328 monoscopic images to determine intergrader reliability. One grader regraded the images after 1 month to determine intragrader reliability. In addition, 85 stereo optic disc images were separately selected, and vertical cup-to-disc ratios were measured using both the new software and standardized Wisconsin manual stereo-grading method by the same grader 1 month apart. Intraclass correlation coefficient (ICC) and Bland–Altman plot analyses were performed. Main Outcome Measures: Optic disc parameters. Results: The intragrader and intergrader reliability for optic disc measurements using Singapore Optic Disc Assessment was high (ICC ranging from 0.82 to 0.94). The mean differences (95% limits of agreement) for intergrader vertical cup-to-disc ratio measurements were 0.00 (−0.12 to 0.13) and 0.03 (−0.15 to 0.09), respectively. The vertical cup-to-disc ratio agreement between the software and Wisconsin grading method was extremely close (ICC = 0.94). The mean difference (95% limits of agreement) of vertical cup-to-disc ratio measurement between the two methods was 0.03 (−0.09 to 0.16). Conclusions: Intragrader and intergrader reliability using Singapore Optic Disc Assessment was excellent. This software was highly comparable with standardized stereo-grading method. Singapore Optic Disc Assessment is useful for grading digital optic disc images in clinical, population-based studies.

PublisherCopyrights

https://oar.a-star.edu.sg/communities-collections/articles/12277

1442-6404

Institute for Infocomm Research