Validity of a new optic disc grading software for use in clinical and epidemiological research

Validity of a new optic disc grading software for use in clinical and epidemiological research
Title:
Validity of a new optic disc grading software for use in clinical and epidemiological research
Other Titles:
Clinical & Experimental Ophthalmology
Keywords:
Publication Date:
25 April 2013
Citation:
Tham, Y.-C., Cheung, C. Y., Wong, T. Y., Baskaran, M., Liu, J., Lee, B.-H., Yin, F., Wong, D. W., Wang, J. J., Mitchell, P., Aung, T. and Cheng, C.-Y. (2013), Validity of a new optic disc grading software for use in clinical and epidemiological research. Clinical & Experimental Ophthalmology, 41: 842–852. doi: 10.1111/ceo.12112
Abstract:
Background: To determine the reliability and agreement of a new optic disc grading software program for use in clinical, epidemiological research. Design: Reliability and agreement study. Samples: 328 monoscopic and 85 stereoscopic optic disc images. Methods: Optic disc parameters were measured using a new optic disc grading software (Singapore Optic Disc Assessment) that is based on polynomial curve-fitting algorithm. Two graders independently graded 328 monoscopic images to determine intergrader reliability. One grader regraded the images after 1 month to determine intragrader reliability. In addition, 85 stereo optic disc images were separately selected, and vertical cup-to-disc ratios were measured using both the new software and standardized Wisconsin manual stereo-grading method by the same grader 1 month apart. Intraclass correlation coefficient (ICC) and Bland–Altman plot analyses were performed. Main Outcome Measures: Optic disc parameters. Results: The intragrader and intergrader reliability for optic disc measurements using Singapore Optic Disc Assessment was high (ICC ranging from 0.82 to 0.94). The mean differences (95% limits of agreement) for intergrader vertical cup-to-disc ratio measurements were 0.00 (−0.12 to 0.13) and 0.03 (−0.15 to 0.09), respectively. The vertical cup-to-disc ratio agreement between the software and Wisconsin grading method was extremely close (ICC = 0.94). The mean difference (95% limits of agreement) of vertical cup-to-disc ratio measurement between the two methods was 0.03 (−0.09 to 0.16). Conclusions: Intragrader and intergrader reliability using Singapore Optic Disc Assessment was excellent. This software was highly comparable with standardized stereo-grading method. Singapore Optic Disc Assessment is useful for grading digital optic disc images in clinical, population-based studies.
License type:
PublisherCopyrights
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Description:
ISSN:
1442-6404
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