Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity

Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity

Human Reproduction

10.1093/humrep/dead247

https://doi.org/10.1093/humrep/dead247

Hamdi Mbarek, Scott D Gordon, David L Duffy, Nikki Hubers, Sally Mortlock, Jeffrey J Beck, Jouke-Jan Hottenga, René Pool, Conor V Dolan, Ky’Era V Actkins, Zachary F Gerring, Jenny van Dongen, Erik A Ehli, William G Iacono, Matt Mcgue, Daniel I Chasman, C Scott Gallagher, Samantha L P Schilit, Cynthia C Morton, Guillaume Paré, Gonneke Willemsen, David C Whiteman, Catherine M Olsen, Catherine Derom, Robert Vlietinck, Daniel Gudbjartsson, Lisa Cannon-Albright, Eva Krapohl, Robert Plomin, Patrik K E Magnusson, Nancy L Pedersen, Pirro Hysi, Massimo Mangino, Timothy D Spector, Teemu Palviainen, Yuri Milaneschi, Brenda W Penninnx, Adrian I Campos, Ken K Ong, John R B Perry, Cornelis B Lambalk, Jaakko Kaprio, Ísleifur Ólafsson, Karine Duroure, Céline Revenu, Miguel E Rentería, Loic Yengo, Lea Davis, Eske M Derks, Sarah E Medland, Hreinn Stefansson, Kari Stefansson, Filippo Del Bene, Bruno Reversade, Grant W Montgomery, Dorret I Boomsma, Nicholas G Martin

05 December 2023

Mbarek, H., Gordon, S. D., Duffy, D. L., Hubers, N., Mortlock, S., Beck, J. J., Hottenga, J.-J., Pool, R., Dolan, C. V., Actkins, K. V., Gerring, Z. F., Van Dongen, J., Ehli, E. A., Iacono, W. G., Mcgue, M., Chasman, D. I., Gallagher, C. S., Schilit, S. L. P., Morton, C. C., … Martin, N. G. (2023). Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity. Human Reproduction, 39(1), 240–257. https://doi.org/10.1093/humrep/dead247

Study question: Which genetic factors regulate female propensity for giving birth to spontaneous dizygotic (DZ) twins? Summary answer: We identified four new loci, GNRH1, FSHR, ZFPM1, and IPO8, in addition to previously identified loci, FSHB and SMAD3. What is known already: The propensity to give birth to DZ twins runs in families. Earlier, we reported that FSHB and SMAD3 as associated with DZ twinning and female fertility measures.

Attribution 4.0 International (CC BY 4.0)

There was no specific funding for the research done

Copyright The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. This is an OpenAccessarticle distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

https://oar.a-star.edu.sg/communities-collections/articles/22589

0268-1161
1460-2350

Genome Institute of Singapore

https://doi.org/10.1093/humrep/dead247