Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis

Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis

Advanced Science

10.1002/advs.202414969

https://doi.org/10.1002/advs.202414969

Xiyao Ni, Yufei Cui, Mojtaba Salehi, Mui Ling Sharon Nai, Kun Zhou, Cian Vyas, Boyang Huang, Paulo Bartolo

19 June 2025

Ni, X., Cui, Y., Salehi, M., Nai, M. L. S., Zhou, K., Vyas, C., Huang, B., & Bartolo, P. (2025). Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis. Advanced Science, 12(32), e14969. https://doi.org/10.1002/advs.202414969

Abstract Piezoelectric biomaterials convert mechanical energy into electrical charges, making them promising candidates for bone tissue engineering by restoring and modulating the electrophysiological microenvironment. This review explores the development of piezoelectric biomaterials by focusing on their molecular origins, particularly dipoles, and how their type, source, and spatial arrangement influence macroscopic electromechanical coupling. Beyond intrinsic origins, the concept of pseudo‐piezoelectricity driven by extrinsic factors is introduced to highlight alternative approaches for piezoelectric biomaterial design. Techniques to engineer dipoles and modulate piezoelectric properties for the regulation of osteogenesis are discussed. Particular attention is given to the correlation between piezoelectricity and osteogenesis at distinct phases of bone regeneration. Finally, current challenges in molecular understanding and biofabrication of piezoelectric bone scaffolds are highlighted, along with potential future research directions.

Attribution 4.0 International (CC BY 4.0)

This research / project is supported by the Nanyang Technological University - Advanced bioprinting strategies for multi-scale and multimaterial tissue engineering
Grant Reference no. :

This is the peer reviewed version of the following article: Ni, X., Cui, Y., Salehi, M., Nai, M. L. S., Zhou, K., Vyas, C., Huang, B., & Bartolo, P. (2025). Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis. Advanced Science, 12(32), e14969. https://doi.org/10.1002/advs.202414969, which has been published in final form at https://doi.org/10.1002/advs.202414969. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

https://oar.a-star.edu.sg/communities-collections/articles/22525

2198-3844
2198-3844

Singapore Institute of Manufacturing Technology

https://doi.org/10.1002/advs.202414969