Pilot study on photoacoustic imaging and confocal Raman spectroscopy-derived biomarkers for assessing structural and physiological skin changes in atopic dermatitis and metabolic diseases

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Pilot study on photoacoustic imaging and confocal Raman spectroscopy-derived biomarkers for assessing structural and physiological skin changes in atopic dermatitis and metabolic diseases
Please use this identifier to cite or link to this item: https://oar.a-star.edu.sg/communities-collections/articles/22484
Title:
Pilot study on photoacoustic imaging and confocal Raman spectroscopy-derived biomarkers for assessing structural and physiological skin changes in atopic dermatitis and metabolic diseases
Journal Title:
Biomedical Optics Express
DOI:
10.1364/BOE.559491
Publication URL:
https://doi.org/10.1364/boe.559491
Authors:
Xiuting Li, Yik Weng Yew, Joshua Shou Yan Lim, Amalina Binte Ebrahim Attia, Renzhe Bi, Mohesh Moothanchery, Steven Tien Guan Thng, Malini Olivo, U. S. Dinish
Keywords:
Biophysics
Publication Date:
16 April 2025
Citation:
Li, X., Yew, Y. W., Lim, J. S. Y., Binte Ebrahim Attia, A., Bi, R., Moothanchery, M., Thng, S. T. G., Olivo, M., & Dinish, U. S. (2025). Pilot study on photoacoustic imaging and confocal Raman spectroscopy-derived biomarkers for assessing structural and physiological skin changes in atopic dermatitis and metabolic diseases. Biomedical Optics Express, 16(7), 2986. https://doi.org/10.1364/boe.559491
Abstract:
Atopic dermatitis (AD), a chronic inflammatory condition, is closely associated with obesity and type 2 diabetes mellitus (diabetes/DM). For the first time, using high-resolution photoacoustic imaging (PAI) and in-house-developed handheld confocal Raman spectroscopy (CRS), we studied in 35 subjects the dermal microvascular architecture, epidermal biochemical profiles and skin alterations in AD with DM and obesity. Utilizing the imaging-derived markers, we observed pronounced dermal hypervascularization in DM and obesity, worsening with AD, as reflected by altered oxygen saturation and epidermal biochemicals. Our findings highlight the role of non-invasive biophotonics techniques in assessing metabolic dysfunction during AD progression and management, underscoring their potential as promising non-invasive tools for real-time skin assessment.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research / project is supported by the National Medical Research Council - Open Fund - Individual Research Grant
Grant Reference no. : OFIRG18nov-0101

This research / project is supported by the Agency for Science, Technology and Research - Central Research Fund
Grant Reference no. :

This research / project is supported by the Agency for Science, Technology and Research - Industry Alignment Fund – Pre-Positioning
Grant Reference no. : H19H6a0025
Description:
©2025 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
URI:
https://oar.a-star.edu.sg/communities-collections/articles/22484
ISSN:
2156-7085
2156-7085
Collections:
A*STAR Skin Research Labs
Files uploaded:
https://doi.org/10.1364/boe.559491