Nemeth, S., & Loke, C. (2025). Estimation of Space and Time Evolution of Mg2+ Concentration Near a Mg2+-Releasing Implant. In 18th International Conference on Biomedical Engineering (pp. 54–68). Springer Nature Switzerland. https://doi.org/10.1007/978-3-032-04372-6_5
Abstract:
According to literature reports based on in vitro tests, transient increase in Mg2+ concentration to 2 to 10 mM can promote osteogenesis around implants. Howev-er, it is not well established how the Mg2+ concentration may change in space and time around a Mg2+-releasing implant in vivo, and whether therapeutic levels of Mg2+ can be maintained in the surrounding tissues. Thus, the temporal and spatial evolution of Mg2+ concentration was investigated from a MgSO4·7H2O contain-ing polycaprolactone implant by numerical analysis using a rudimentary diffusion model. Diffusion coefficient of Mg2+ in polycaprolactone was determined exper-imentally, while it was estimated in body fluids and tissue from literature data. The results revealed that Mg2+ levels generally increase modestly and reach the therapeutic level for less than one day in this system due to fast clearing of Mg2+ from the tissues. Toxic levels of Mg2+ concentration may develop, but only for a few minutes, and can be mitigated by a thin layer of pure polymer applied on the implant.
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Publisher Copyright
Funding Info:
This research / project is supported by the A*STAR - RIE2025 Manufacturing, Trade and Connectivity (MTC) Industry Alignment Fund Industry Collaboration Projects (IAF-ICP)
Grant Reference no. : I2101E0010
Description:
This is a post-peer-review, pre-copyedit version of an article published in IFMBE Proceedings. The final authenticated version is available online at: http://dx.doi.org/10.1007/978-3-032-04372-6_5.