Mehta, K. H., I Made, R., Parkin, I. P., Sankar, G., & Handoko, A. D. (2025). A Paradigm Shift: From Batch Processing to Flow Chemistry. Small, 21(24). Portico. https://doi.org/10.1002/smll.202411519
Abstract:
Customisable flow chemistry reactors are becoming more affordable and accessible to wider research community. Coupled with rapidly advancing machine learning (ML) optimisation algorithms, time consuming research activities like catalyst discovery, reaction screening and optimisation can now be achievable quicker in flow, placing us in an interesting crossroad: should we start thinking about flow integration earlier in the research phase? In this perspective, parallels and differences between batch and flow heterogeneous catalytic reaction optimisations will be discussed with practical examples. Challenges in flow and batch processing are compared, combined with fresh perspectives of how reaction conditions can be adjusted more flexibly in multi‐pass flow setting. Finally, recent progress of integrating computational techniques into flow process optimisation of contemporary “chemical looping” and paired reactions for more sustainable chemical productions will also be discussed.
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Publisher Copyright
Funding Info:
This research / project is supported by the A*STAR Horizontal Technology Coordinating Office - Seed Funding
Grant Reference no. : C231218004
This research / project is supported by the Agency for Science, Technology and Research - Research Attachment Programme
Grant Reference no. : HQ/R25-ARAP210202
This research / project is supported by the Agency for Science, Technology and Research - RIE2020 Advanced Manufacturing and Engineering (AME) Programmatic Fund
Grant Reference no. : A20G9b0135 (PLRI210201dSERASN)
This research / project is supported by the Agency for Science, Technology and Research - RIE2025 Manufacturing, Trade and Connectivity (MTC) - Industry Alignment Fund Pre-Positioning (IAF-PP)
Grant Reference no. : M22K8a0048 (OUNI231001bENT-PP)
Description:
This is the peer reviewed version of the following article: Mehta, K. H., I Made, R., Parkin, I. P., Sankar, G., & Handoko, A. D. (2025). A Paradigm Shift: From Batch Processing to Flow Chemistry. Small, 21(24). Portico. https://doi.org/10.1002/smll.202411519, which has been published in final form at https://doi.org/10.1002/smll.202411519. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.