Non‐invasive biochemical analysis and comparison of atopic dermatitis and psoriasis skin using handheld confocal Raman spectroscopy

Non‐invasive biochemical analysis and comparison of atopic dermatitis and psoriasis skin using handheld confocal Raman spectroscopy

Journal of Biophotonics

10.1002/jbio.202300191

https://doi.org/10.1002/jbio.202300191

U. S. Dinish, Yik Weng Yew, Keertana Vinod Ram, Renzhe Bi, Amalina Binte Ebrahim Attia, Valerie Teo Xinhui, Poongkulali Rajarahm, Hazel Hweeboon Oon, Steven Tien Guan Thng, Malini Olivo

10 August 2023

Dinish, U. S., Yew, Y. W., Vinod Ram, K., Bi, R., Attia, A. B. E., Teo Xinhui, V., Rajarahm, P., Oon, H. H., Thng, S. T. G., & Olivo, M. (2023). Non‐invasive biochemical analysis and comparison of atopic dermatitis and psoriasis skin using handheld confocal Raman spectroscopy. Journal of Biophotonics, 16(12). Portico. https://doi.org/10.1002/jbio.202300191

A handheld non‐invasive confocal Raman system (CRS) was used to evaluate the differences in skin biochemicals between atopic dermatitis (AD) and psoriasis, which are inflammatory skin conditions. Raman spectral measurements in the fingerprint and high wavenumber region were acquired using a portable in‐house CRS system with excitation lasers operating at 671 and 785 nm. It was deduced that relative amount of water decreases in the following sequence of skin: healthy, psoriasis and AD. Moreover, differential trends were observed for the subclasses of ceramides such that ceramide 3 is lower in the lesional AD and psoriasis skin as compared to healthy, while ceramide 2 showed a contrasting trend of decrease in lesional AD and increase in lesional psoriasis as opposed to healthy skin. Amount of cholesterol was significantly higher in lesional psoriasis as compared to lesional AD and healthy skin. These differences can aid in an objective classification of the skin conditions and in the formulation of new disease‐specific topical treatments.

Publisher Copyright

This research / project is supported by the Agency for Science, Technology and Research - Industry Alignment Fund - Pre-Positioning
Grant Reference no. : H19H6a0025

This research / project is supported by the Agency for Science, Technology and Research - Intramural Funding
Grant Reference no. : NA

This is the peer reviewed version of the following article: Dinish, U. S., Yew, Y. W., Vinod Ram, K., Bi, R., Attia, A. B. E., Teo Xinhui, V., Rajarahm, P., Oon, H. H., Thng, S. T. G., & Olivo, M. (2023). Non‐invasive biochemical analysis and comparison of atopic dermatitis and psoriasis skin using handheld confocal Raman spectroscopy. Journal of Biophotonics, 16(12). Portico, which has been published in final form at https://doi.org/10.1002/jbio.202300191. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited

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