Resting-state EEG biomarkers of accelerated intermittent theta burst stimulation treatment for depression: a pilot study

Page view(s)
15
Checked on Feb 09, 2025
Resting-state EEG biomarkers of accelerated intermittent theta burst stimulation treatment for depression: a pilot study
Title:
Resting-state EEG biomarkers of accelerated intermittent theta burst stimulation treatment for depression: a pilot study
Journal Title:
46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
DOI:
Keywords:
Publication Date:
31 December 2024
Citation:
Guo, L., Zhang, Z., Tan, X. W., Phua, K., Wang, C., Tor, P. C. & Ang, K. K. (2024). Resting-state EEG biomarkers of accelerated intermittent theta burst stimulation treatment for depression: a pilot study. 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).
Abstract:
Accelerated intermittent theta burst stimulation (aiTBS) is a novel and effective treatment for drug-resistant depression. While past studies have identified encephalography (EEG) features predicting repetitive transcranial magnetic stimulation (rTMS) outcomes, EEG biomarkers specifically for aiTBS in depression patients have not been explored. In this pilot trial on 5 depression patients undergoing aiTBS, we assessed clinical outcome using the Montgomery-Asberg Depression Rating Scale (MADRS) and collected resting-state EEG pre and post-treatment. All patients showed an improvement in MADRS, with 3 having at least 50% improvement. We found significant correlations between MADRS change and pre-treatment frontal beta power, midline frontal Lempel-Ziv Complexity (LZC) and alpha connectivity. We also observed a trend of increased frontal theta power post-treatment. However, no significant correlations emerged between MADRS change and change in EEG feature post-treatment. This preliminary trial highlights the potential for investigating aiTBS-specific EEG biomarkers, paving the way for larger studies to enhance personalized neurostimulation and predict treatment outcomes in drug-resistant depression patients.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the Singapore National Health Group (NHG) Centre for Medical Technologies & Innovations (CMTi) - MedTech Grant
Grant Reference no. : CMTi-21-01-01

This research / project is supported by the A*STAR - Strategic Programme Funds
Grant Reference no. : C211817001 Brain Body Initiative
Description:
© 2024 IEEE.  Personal use of this material is permitted.  Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
ISSN:
979-8-3503-7149-9
Files uploaded:

File Size Format Action
embc-tms-eeg-final.pdf 271.97 KB PDF Request a copy