Filaggrin Null Mutations Are Not a Protective Factor for Acne Vulgaris

Filaggrin Null Mutations Are Not a Protective Factor for Acne Vulgaris

Journal of Investigative Dermatology

10.1038/jid.2011.23

https://pmc.ncbi.nlm.nih.gov/articles/PMC3094589/

John E.A. Common, Sara J. Brown, Rebecca L. Haines, Christabelle S.M. Goh, Huijia Chen, Anita Balakrishnan, Colin S. Munro, Audrey W.H. Tan, H.H. Tan, Mark B.Y. Tang, E. Birgitte Lane

Genetics and Molecular Biology

17 February 2011

Common, J. E. A., Brown, S. J., Haines, R. L., Goh, C. S. M., Chen, H., Balakrishnan, A., Munro, C. S., Tan, A. W. H., Tan, H. H., Tang, M. B. Y., & Lane, E. B. (2011). Filaggrin Null Mutations Are Not a Protective Factor for Acne Vulgaris. Journal of Investigative Dermatology, 131(6), 1378–1380. https://doi.org/10.1038/jid.2011.23

Acne vulgaris is a very common skin disorder, affecting to some degree 88–94% of Singaporean adolescents (Tan et al., 2007; Yosipovitch et al., 2007). Genetic predisposition is a significant risk factor, as illustrated by familial and twin studies (Bataille et al., 2002; Ghodsi et al., 2009). The clinical features of acne include sebor-rhea, comedone formation, inflammatory pustules, nodules, and cysts, with resultant scarring. Important pathogenic mechanisms in acne include increased sebum production, hyperkeratinization and occlusion of the follicular duct, proliferation of Propionibacterium acnes, and an inflammatory reaction (Purdy and de Berker, 2006). P. acnes produces lipases, which liberate proinflammatory fatty acids from sebum and also triggers a cytokine response.

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This research is supported by core funding from: Agency of Science, Technology and Research (A*STAR)
Grant Reference no. : NA

This research / project is supported by the Wellcome Trust Intermediate Fellowship - N/A
Grant Reference no. : 086398/Z/08/Z

This research / project is supported by the National Medical Research Council, Singapore - Enabling Grant
Grant Reference no. :

https://oar.a-star.edu.sg/communities-collections/articles/20147

0022-202X

Skin Research Lab