Fuentes, I., Guttmann-Gruber, C., Tay, A. S. L., Piñón Hofbauer, J., Denil, S. L. I. J., Reichelt, J., Palisson, F., Common, J. E. A., & South, A. P. (2018). Reduced Microbial Diversity Is a Feature of Recessive Dystrophic Epidermolysis Bullosa-Involved Skin and Wounds. Journal of Investigative Dermatology, 138(11), 2492–2495. https://doi.org/10.1016/j.jid.2018.04.026
Abstract:
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited skin disease characterized by
epidermal fragility leading to chronic wounds (Fine et al., 2014). RDEB is complicated by other pathologies such
as esophageal strictures, anemia, mitten deformity, and corneal abrasion, but poor wound healing has arguably the greatest impact on quality of life and ultimately leads to the development of highly aggressive squamous cell carcinoma (Fine et al.,2009). One of the defining features of RDEB wounds is that when they do
heal, they do so with evident scarring. Because both scar formation and wound-induced cancer have previously been linked to microbial infection in murine studies (Canesso et al.,2014; Hoste et al., 2015), and because recent data suggest deficiencies in antibacterial immunity in RDEB patients (Nystrom et al.,2018), we sought to profile the microbiome of RDEB skin and wounds using shotgun whole-metagenome sequencing, a technique not previously used, to our knowledge, for analyzing this patient group.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research was supported by DEBRA Austria.
This research / project is supported by the Agency for Science, Technology and Research - Strategic Positioning Fund (SPF) grants for basic and translational skin research
Grant Reference no. : IAF SPF 2013/004, IAF SPF 2013/005