Saunders, T.E., Ingham, P.W. Open questions: how to get developmental biology into shape?. BMC Biol 17, 17 (2019). https://doi.org/10.1186/s12915-019-0636-6
Recent technical advances have provided unprecedented insights into the selective deployment of the genome in developing organisms, but how such differential gene expression is used to sculpt the complex shapes and sizes of organs remains unclear. Here, we outline major open questions in organogenesis and suggest how a synthesis between developmental biology and physics can help to address them.
TES was funded by a Singapore National Research Foundation Fellowship (NRF2012NRF-NRFF001–094) and HFSP Young Investigator Grant (RGY0083/2016).