Characteristics of extracellular vesicles released by epidermal keratinocytes

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Characteristics of extracellular vesicles released by epidermal keratinocytes
Title:
Characteristics of extracellular vesicles released by epidermal keratinocytes
Other Titles:
Journal of the European Academy of Dermatology and Venereology
Publication Date:
12 August 2019
Citation:
Eur Acad Dermatol Venereol . 2019 Dec;33(12):2264-2272. doi: 10.1111/jdv.15859.
Abstract:
Keratinocytes, which constitute 90% of the cells in the epidermis of the skin, have been demonstrated to communicate with other skin cells such as fibroblasts, melanocytes and immune cells through extracellular vesicles (EVs). This communication is facilitated by the enriched EV biomolecular cargo which regulates multiple biological processes within skin tissue, including cell proliferation, cell migration, anti-apoptosis, pigmentation transfer and extracellular matrix remodelling. This review will provide an overview of the current literature and advances in the field of keratinocyte-derived EV research with particular regard to the interactions and communication between keratinocytes and other skin cells, mediated by EVs and EV components. Importantly, this information may shed some light on the potential for keratinocyte-derived EVs in future biomedical studies.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the HBMS - IAF-PP
Grant Reference no. : H17/01/a0/009
Description:
This is the peer reviewed version of the following article: TT Uyen Than, Leavesley D, Parker T. Characteristics of extracellular vesicles released by epidermal keratinocytes. J Euro Acad Dermatol Venereol. 33: 2264-2272, 2019, which has been published in final form at DOI: 10.1111/jdv.15859. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
ISSN:
1468-3083
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