Deveaux, W., Selvarajoo, K. Searching for simple rules in Pseudomonas aeruginosa biofilm formation. BMC Res Notes 12, 763 (2019). https://doi.org/10.1186/s13104-019-4795-x
Abstract:
Objective
Living cells display complex and non-linear behaviors, especially when posed to environmental threats. Here, to understand the self-organizing cooperative behavior of a microorganism Pseudomonas aeruginosa, we developed a discrete spatiotemporal cellular automata model based on simple physical rules, similar to Conway’s game of life.
Results
The time evolution model simulations were experimentally verified for P. aeruginosa biofilm for both control and antibiotic azithromycin (AZM) treated condition. Our model suggests that AZM regulates the single cell motility, thereby resulting in delayed, but not abolished, biofilm formation. In addition, the model highlights the importance of reproduction by cell to cell interaction is key for biofilm formation. Overall, this work highlights another example where biological evolutionary complexity may be interpreted using rules taken from theoretical disciplines.
License type:
http://creativecommons.org/licenses/by-nd/4.0/
Funding Info:
The authors thank BioTrans for funding (IAF-PP) the modeling work. The funder played no role in study design; collection, analysis, and interpretation of data; writing of the report; or in the decision to submit the article for publication.
H17/01/a0/006
Description:
Open Access publication: https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4795-x