C. Ren, F. Chen, R. Ye, Y. S. Ong, H. Lu, S. S. Lee, J. Y. Ying, H. Zeng, Angew. Chem. Int. Ed. 2019 , 58 , 8034.
Abstract:
Ions are transported across membrane mostly via carrier or channel mechanisms.Herein, a unique class of molecular-machine-inspired membrane transporters, termed molecular swings is reported that utilize a previously unexplored swing mechanism for promoting ion transport in a highly efficient manner. In particular,the molecular swing,which carries a 15-crown-5 unit as the ion-binding and transporting unit, exhibits extremely high ion-transport activities with EC50 values of 46 nm (a channel:lipid molar ratio of 1:4800 or 0.021 mol%relative to lipid) and 110 nm for K+and Na+ions,respectively.Remarkably,such ion transport activities remain high in a cholesterol-rich environment, with EC50 values of 130 (0.045 mol%relative to lipid/cholesterol) and 326 nm for K+and Na+ions, respectively.
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Funding Info:
This research is supported by core funding from Institute of Bioengineering and Nanotechnology, and NanoBio Lab.
Description:
This is the peer reviewed version of the following article: C. Ren, F. Chen, R. Ye, Y. S. Ong, H. Lu, S. S. Lee, J. Y. Ying, H. Zeng, Angew. Chem. Int. Ed. 2019 , 58 , 8034., which has been published in final form at https://doi.org/10.1002/anie.201901833. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.