Therapeutics targeting the fibrinolytic system

Therapeutics targeting the fibrinolytic system
Title:
Therapeutics targeting the fibrinolytic system
Other Titles:
Experimental & Molecular Medicine
Keywords:
Publication Date:
09 March 2020
Citation:
Lin, H., Xu, L., Yu, S. et al. Therapeutics targeting the fibrinolytic system. Exp Mol Med 52, 367–379 (2020). https://doi.org/10.1038/s12276-020-0397-x
Abstract:
The function of the fibrinolytic system was first identified to dissolve fibrin to maintain vascular patency. Connections between the fibrinolytic system and many other physiological and pathological processes have been well established. Dysregulation of the fibrinolytic system is closely associated with multiple pathological conditions, including thrombosis, inflammation, cancer progression, and neuropathies. Thus, molecules in the fibrinolytic system are potent therapeutic and diagnostic targets. This review summarizes the currently used agents targeting this system and the development of novel therapeutic strategies in experimental studies. Future directions for the development of modulators of the fibrinolytic system are also discussed.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
This work was supported by the Natural Science Foundation of Fujian Province (2018J0105, 2018J05031), grants from the National Key R&D Program of China (2017YFE0103200), and the Natural Science Foundation of China (21708043, 31400637, 31670739). Natural Science Foundation of Fujian Province (2018J0105, 2018J05031). National Key R&D Program of China (2017YFE0103200). National Natural Science Foundation of China (21708043, 31400637, 31670739).
Description:
ISSN:
1226-3613
2092-6413
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