Human mesenchymal stem cell therapy for cartilage repair: Review on isolation, expansion, and constructs

Human mesenchymal stem cell therapy for cartilage repair: Review on isolation, expansion, and constructs
Title:
Human mesenchymal stem cell therapy for cartilage repair: Review on isolation, expansion, and constructs
Other Titles:
Stem Cell Research
Keywords:
Publication Date:
18 February 2020
Citation:
Alan T.L. Lam, Shaul Reuveny, Steve Kah-Weng Oh, Human mesenchymal stem cell therapy for cartilage repair: Review on isolation, expansion, and constructs, Stem Cell Research, Volume 44, 2020, 101738, ISSN 1873-5061, https://doi.org/10.1016/j.scr.2020.101738.
Abstract:
Articular cartilage defects are one of the major challenges in orthopedic and trauma surgery. However, the poor ability of cartilage to self-repair has motivated efforts to engineer replacement tissues, and human mesenchymal stem cells (MSC), which have an extensive proliferation potential and can undergo chondrogenesis, have emerged as a promising cell source. In this review, we attempt to provide a brief overview of MSC isolation, characterization, current manufacturing platforms using various bioreactors, in vitro differentiation, and sealant-based or scaffold-based implantation.
License type:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Funding Info:
This work was supported by Industry Alignment Fund- Prepositioning (IAF-PP) grants from the Health and Biomedical Sciences(HBMS), Singapore (H1801a0021) .
Description:
ISSN:
1873-5061
1876-7753
Files uploaded:
File Size Format Action
There are no attached files.