Transcriptome alterations of vascular smooth muscle cells in aortic wall of myocardial infarction patients

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Transcriptome alterations of vascular smooth muscle cells in aortic wall of myocardial infarction patients
Title:
Transcriptome alterations of vascular smooth muscle cells in aortic wall of myocardial infarction patients
Journal Title:
Data in Brief
Keywords:
Publication Date:
06 February 2018
Citation:
Thidathip Wongsurawat, Chin Cheng Woo, Antonis Giannakakis, Xiao Yun Lin, Esther Sok Hwee Cheow, Chuen Neng Lee, Mark Richards, Siu Kwan Sze, Intawat Nookaew, Vladimir A. Kuznetsov, Vitaly Sorokin, Transcriptome alterations of vascular smooth muscle cells in aortic wall of myocardial infarction patients, Data in Brief, Volume 17, 2018, Pages 1112-1135, ISSN 2352-3409, https://doi.org/10.1016/j.dib.2018.01.108.
Abstract:
This article contains further data and information from our published manuscript [1]. We aim to identify significant transcriptome alterations of vascular smooth muscle cells (VSMCs) in the aortic wall of myocardial infarction (MI) patients. Microarray gene analysis was applied to evaluate VSMCs of MI and non-MI patients. Prediction Analysis of Microarray (PAM) identified genes that significantly discriminated the two groups of samples. Incorporation of gene ontology (GO) identified a VSMCs-associated classifier that discriminated between the two groups of samples. Mass spectrometry-based iTRAQ analysis revealed proteins significantly differentiating these two groups of samples. Ingenuity Pathway Analysis (IPA) revealed top pathways associated with hypoxia signaling in cardiovascular system. Enrichment analysis of these proteins suggested an activated pathway, and an integrated transcriptome-proteome pathway analysis revealed that it is the most implicated pathway. The intersection of the top candidate molecules from the transcriptome and proteome highlighted overexpression.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
Description:
ISSN:
2352-3409
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