High nuclearity carbonyl clusters as near-IR contrast agents for photoacoustic in vivo imaging

High nuclearity carbonyl clusters as near-IR contrast agents for photoacoustic in vivo imaging
Title:
High nuclearity carbonyl clusters as near-IR contrast agents for photoacoustic in vivo imaging
Other Titles:
Journal of Materials Chemistry B
DOI:
10.1039/C6TB00075D
Keywords:
Publication Date:
03 May 2016
Citation:
Abstract:
High nuclearity carbonyl clusters of ruthenium and osmium are found to exhibit good photoacoustic (PA) activity in the near-IR (NIR) region. Their potential as PA contrast agents for full body imaging has been demonstrated for the first time with mice; intravenous administration of the osmium carbonyl cluster Na2[Os10(μ6-C)(CO)24] afforded up to a four-fold enhancement of the PA signal in various tissues. The cluster exhibits low toxicity, high stability and superior PA stability compared to the clinically approved NIR dye, indocyanine green.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
Description:
ISSN:
2050-750X
2050-7518
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