Novel Biodegradable Polymer Tethered Platinum (II) for Photoacoustic Imaging

Novel Biodegradable Polymer Tethered Platinum (II) for Photoacoustic Imaging
Title:
Novel Biodegradable Polymer Tethered Platinum (II) for Photoacoustic Imaging
Other Titles:
Journal of Nanomedicine & Nanotechnology
DOI:
10.4172/2157-7439.1000223
Keywords:
Publication Date:
30 August 2014
Citation:
Kong KV, Liao LD, Goh D, Thakor NV, Olivo M (2014) Novel Biodegradable Polymer Tethered Platinum (II) for Photoacoustic Imaging. J Nanomed Nanotechnol 5:223. doi:10.4172/2157-7439.1000223
Abstract:
Photoacoustic microscopy (PAM) is an emerging imaging diagnostic technique for various diseases. Coupled with contrast agents, photoacoustic (PA) imaging yields additional information to facilitate an accurate diagnosis. While many organic-based contrast agents, notably those of cyanine dyes, nanoparticles, polyhydroxy-fullerene and carbon nanotubes, have become available, the use of transition metal as contrast agent is scant. Here, for the first time, we report a platinum II-based biodegradable polymer for PA imaging that is capable of effective cellular internalization with very low cytotoxicity. The experiment results show great promise as a novel photoacoustic contrast agent as its detectable PA signal was observed both in cell imaging and in vivo rat cerebral vascular imaging via designed PAM. This work exemplifies the incorporation of transition metal complex with polymeric nanoparticles, further expanding the field of the ability of PA imaging.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
Description:
ISSN:
2157-7439
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