Dong, Y. C.; Ng, W. K.; Hu, J.; Shen, S. C.; Tan, R. B. H., Continuous production of redispersible and rapidly-dissolved fenofibrate nanoformulation by combination of microfluidics and spray drying. Powder Technology 2014, 268, p 424-428.
Abstract:
Slow dissolution rate is responsible for poor oral bioavailability of fenofibrate. This work aimed at synthesizing a redispersible and rapidly-dissolved fenofibrate nanoformulation by combination of antisolvent precipitation-in-microfluidics and spray drying. 196–296 nm fenofibrate nanoparticles (NPs) were achieved by the developed process. Increasing the volume ratio of the antisolvent water to drug ethanolic solution, flow rate or drug concentration resulted in the formation of smaller particles. Fenofibrate nanoformulation exhibited good redispersibility and much faster dissolution rate in comparison with the raw drug.
License type:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Funding Info:
This work was funded by project grant ICES/11-222A03 from A*STAR (Agency for Science, Technology and Research) of Singapore.