Koh, L. F., Ng, B. K., Bertrand, J. and Thierry, F. (2015), Transcriptional control of late differentiation in human keratinocytes by TAp63 and Notch. Experimental Dermatology, 24: 754–760. doi: 10.1111/exd.12764
Abstract:
We previously showed that in cervical carcinoma cells, the TAp63β isoform of the p63 transcription factor is negatively interfering with the carcinogenic pathways promoting anchorage-independent growth. In this study, we have defined the mechanisms underlying the effects of TAp63β through a transcriptome analysis of human keratinocytes overexpressing this protein. TAp63β modulated expression of 1203 genes (944 activated and 259 repressed; P-value