Tandem oxidative amidation of benzyl alcohols with amine hydrochloride salts catalysed by iron nitrate

Tandem oxidative amidation of benzyl alcohols with amine hydrochloride salts catalysed by iron nitrate
Title:
Tandem oxidative amidation of benzyl alcohols with amine hydrochloride salts catalysed by iron nitrate
Other Titles:
Tetrahedron Letters
Keywords:
Publication Date:
04 September 2013
Citation:
Ghosh, S. C.; Ngiam, J. S. Y.; Seayad, A. M.; Dang, T. T.; Johannes, C. W.; Chen, A. Q., Tandem oxidative amidation of benzyl alcohols with amine hydrochloride salts catalysed by iron nitrate. Tetrahedron Letters 2013, 54, (36), p 4922-4925.
Abstract:
A tandem process for the oxidative amidation of benzyl alcohols with amine hydrochloride salts has been developed using inexpensive Fe(NO3)3 as the catalyst, air and aqueous t-butyl hydroperoxide as oxidants. A wide range of benzamides have been synthesized under mild conditions. This greener amide formation method provides an economical and practical assess to benzamides from readily available and inexpensive starting materials.
License type:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Funding Info:
This work was supported by the GlaxoSmithKline (GSK), Singapore Economic Development Board (EDB) for Green and Sustainable Manufacturing (GSM) and the Agency for Science, Technology and Research (A*STAR), Singapore.
Description:
ISSN:
0040-4039
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