A facile method for the fabrication of Quantum Dot/poly(N-iso-propylacrylamide) (QD/PNIPAM) micropatterns on glass is presented. Water-soluble QDs functionalized with polymerizable methacrylic groups effectively copolymerize with N-isopropylacrylamide monomer resulting in stable hybrid organic–inorganic networks. The patterns display temperature and pH responsive luminescence behaviour.