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8 Nov 2024
SERC
Institute of Sustainability for Chemicals, Energy and Environment
A Machine Learning-Guided Approach to Navigate the Substrate Activity Scope of Galactose Oxidase: Application in the Conversion of Pharmaceutically Relevant Bulky Secondary Alcohols
Shreyas Supekar,
Dillon W. P. Tay,
Wan Lin Yeo,
Kwok Wai Eric Tam,
Ying Sin Koo,
Jie Yang See,
Jhoann M. T. Miyajima,
Sebastian Maurer-Stroh,
Ee Lui Ang,
Yee Hwee Lim,
Hao Fan
ACS Catalysis
1 Dec 2023
BMRC
Singapore Institute of Food and Biotechnology Innovation
Directed Evolution and Computational Modeling of Galactose Oxidase toward Bulky Benzylic and Alkyl Secondary Alcohols
Wan Lin Yeo,
Dillon W. P. Tay,
Jhoann M.T. Miyajima,
Shreyas Supekar,
Tong Mei Teh,
Jin Xu,
Yee Ling Tan,
Jie Yang See,
Hao Fan,
Sebastian Maurer-Stroh,
Yee Hwee Lim,
Ee Lui Ang
ACS Catalysis
19 Mar 2020
BMRC
Bioinformatics Institute
Identification and engineering of 32 membered antifungal macrolactone notonesomycins
Falicia Goh,
Mingzi M. Zhang,
Tian Ru Lim,
Kia Ngee Low,
Choy Eng Nge,
Elena Heng,
Wan Lin Yeo,
Fernanda L. Sirota,
Sharon Crasta,
Zann Tan,
Veronica Ng,
Chung Yan Leong,
Hubin Zhang,
Alexander Lezhava,
Swaine L. Chen,
Shawn S. Hoon,
Frank Eisenhaber,
Birgit Eisenhaber,
Yoganathan Kanagasundaram,
Fong T. Wong,
Siew Bee Ng
Microbial Cell Factories
6 Jan 2020
BMRC
Singapore Institute of Food and Biotechnology Innovation
Biosynthetic engineering of the antifungal, anti‑MRSA auroramycin
Wan Lin Yeo,
Elena Heng,
Lee Ling Tan,
Yi Wee Lim,
Kuan Chieh Ching,
De‐Juin Tsai,
Yi Wun Jhang,
Tsai‐Ling Lauderdale,
Kak‐Shan Shia,
Huimin Zhao,
Ee Lui Ang,
Mingzi Zhang,
Yee Hwee Lim,
Fong Tian Wong
Microbial Cell Factories
10 Jun 2019
BMRC
Bioinformatics Institute
Chemogenomic profiling in yeast reveals antifungal mode-of-action of polyene macrolactam auroramycin
Jin Huei Wong,
Mohammad Alfatah,
Kiat Whye Kong,
Shawn Hoon,
Wan Lin Yeo,
Kuan Chieh Ching,
Corinna Jie Hui Goh,
Mingzi M. Zhang,
Yee Hwee Lim,
Fong Tian Wong,
Prakash Arumugam
PLOS ONE
15 May 2019
BMRC
Singapore Institute of Food and Biotechnology Innovation
Characterization of Cas proteins for CRISPR‐Cas editing in streptomycetes
Wan Lin Yeo,
Elena Heng,
Lee Ling Tan,
Yi Wee Lim,
Yee Hwee Lim,
Shawn Hoon,
Huimin Zhao,
Mingzi Zhang,
Fong Tian Wong
Biotechnology and Bioengineering
25 May 2018
BMRC
Singapore Institute of Food and Biotechnology Innovation
Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR‐Cas9 Activation
Yee Hwee Lim,
Fong Tian Wong,
Wan Lin Yeo,
Kuan Chieh Ching,
Yi Wee Lim,
Elena Heng,
Shuwen Chen,
De‐Juin Tsai,
Tsai‐Ling Lauderdale,
Kak‐Shan Shia,
Ying Swan Ho,
Shawn Hoon,
Ee Lui Ang,
Mingzi Zhang,
Huimin Zhao
ChemBioChem
10 Apr 2017
BMRC
Singapore Institute of Food and Biotechnology Innovation
CRISPR–Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters
Mingzi Zhang,
Fong Tian Wong,
Yajie Wang,
Shangwen Luo,
Yee Hwee Lim,
Elena Heng,
Wan Lin Yeo,
Ryan E Cobb,
Behnam Enghiad,
Ee Lui Ang,
Huimin Zhao
Nature Chemical Biology
27 Jan 2017
BMRC
Singapore Institute of Food and Biotechnology Innovation
Probing the Molecular Determinants of Fluorinase Specificity
Wan Lin Yeo,
Xinying Chew,
Derek John Smith,
Kok Ping Chan,
Huihua Sun,
Huimin Zhao,
Yee Hwee Lim,
Ee Lui Ang
Chemical Communications
14 Oct 2016
BMRC
Singapore Institute of Food and Biotechnology Innovation
Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate
Huihua Sun,
Wan Lin Yeo,
Yee Hwee Lim,
Xinying Chew,
Derek John Smith,
Bo Xue,
Kok Ping Chan,
Robert C. Robinson,
Edward G. Robins,
Huimin Zhao,
Ee Lui Ang
Angewandte Chemie International Edition
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