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25 Mar 2020 Others Bioinformatics Institute A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma Nur Afiqah Binte Mohamed Salleh, Richard Weijie Ong, Li Ren Kong, Tuan Zea Tan, Nicholas L. Syn, Robby Miguel Goh, Chee Wai Fhu, Daniel S W Tan, Gopalakrishna Iyer, Srinivasaraghavan Kannan, Chandra S. Verma, Yaw Chyn Lim, Ross Soo, Jingshan Ho, Yiqing Huang, Joline S. J. Lim, Benedict Junrong Yan, Min En Nga, Seng Gee Lim, H. Philip Koeffler, Soo Chin Lee, Dennis Kappei, Huyhn The Hung, Boon Cher Goh Nature Communications
1 Feb 2020 BMRC Institute of Molecular and Cell Biology AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells Maria L. Lotsberg, Katarzyna Wnuk-Lipinska, Stéphane Terry, Tuan Zea Tan, Ning Lu, Laura Trachsel-Moncho, Gro V. Røsland, Muntequa I. Siraji, Monica Hellesøy, Austin Rayford, Kirstine Jacobsen, Henrik J. Ditzel, Olav K. Vintermyr, Trever G. Bivona, John Minna, Rolf A. Brekken, Bruce Baguley, David Micklem, Lars A. Akslen, Gro Gausdal, Anne Simonsen, Jean Paul Thiery, Salem Chouaib, James B. Lorens, Agnete Svendsen Tenfjord Engelsen Journal of Thoracic Oncology
25 Sep 2019 Others Bioinformatics Institute c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression Wen Jing Sim, Prasanna Vasudevan Iyengar, Dilraj Lama, Sara Kit Leng Lui, Hsien Chun Ng, Lior Haviv-Shapira, Eytan Domany, Dennis Kappei, Tuan Zea Tan, Azad Saie, Patrick William Jaynes, Chandra Shekhar Verma, Hong Koo Ha, Camelia Radulescu, Peter ten Dijke, Pieter Johan Adam Eichhorn, Jean Paul Thiery, Alan Prem Kumar, Mathieu Rouanne Nature Communications
1 Jun 2019 BMRC Institute of Molecular and Cell Biology Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC Gro V. Røsland, Sissel E. Dyrstad, Deusdedit Tusubira, Reham Helwa, Tuan Zea Tan, Maria L. Lotsberg, Ina K. N. Pettersen, Anna Berg, Charlotte Kindt, Fredrik Hoel, Kirstine Jacobsen, Ari J. Arason, Agnete S. T. Engelsen, Henrik J. Ditzel, Per E. Lønning, Camilla Krakstad, Jean P. Thiery, James B. Lorens, Stian Knappskog, Karl J. Tronstad Cancer & Metabolism
11 Dec 2018 BMRC Institute of Molecular and Cell Biology The FZD 7‐TWIST 1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma Clare Scott, Ruby Yun‐Ju Huang, Ming Tan, Mohammad Asad, Valerie Heong, Meng Kang Wong, Tuan Zea Tan, Jieru Ye, Kuee Theng Kuay, Jean Paul Thiery Molecular Oncology
15 Jun 2018 BMRC Institute of Molecular and Cell Biology The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer Jane Antony, Elisa Zanini, Zoe Kelly, Tuan Zea Tan, Evdoxia Karali, Mohammad Alomary, Youngrock Jung, Katherine Nixon, Paula Cunnea, Christina Fotopoulou, Andrew Paterson, Sushmita Roy‐Nawathe, Gordon B Mills, Ruby Yun‐Ju Huang, Jean Paul Thiery, Hani Gabra, Chiara Recchi EMBO Reports
7 Mar 2018 BMRC Institute of Molecular and Cell Biology A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase Jianbiao Zhou, Sabrina Hui-Min Toh, Zit-Liang Chan, Jessie Yiying Quah, Jing-Yuan Chooi, Tuan Zea Tan, Phyllis S. Y. Chong, Qi Zeng, Wee-Joo Chng Journal of Hematology & Oncology
27 May 2015 BMRC Institute of Molecular and Cell Biology Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120) Ruby Yun-Ju Huang, Kuee Theng Kuay, Tuan Zea Tan, Aloysius Hsien Chun Ng, Jieru Ye, Vin Yee Chung, Mohammad Asad, Hei Mui Tang, Jean Paul Thiery Oncotarget
6 May 2015 BMRC Institute of Molecular and Cell Biology Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy Prashant Kumar, Sayantani Nandi, Bee Luan Khoo, Soo Chin Lee, Tuan Zea Tan, Majid Ebrahimi Warkiani, Samuel GW Ow, Chwee Teck Lim, Jean Paul Thiery Oncotarget
15 Apr 2015 BMRC Institute of Molecular and Cell Biology Highly sensitive and specific novel biomarkers for the diagnosis of transitional bladder carcinoma Prashant Kumar, Sayantani Nandi, Tuan Zea Tan, Siok Ghee Ler, Kee Seng Chia, Wei-Yen Lim, Zentia Bütow, Dimitrios Vordos, Alexandre De laTaille, Muthafar Al-Haddawi, Manfred Raida, Burkhard Beyer, Estelle Ricci, Marc Colombel, Tsung Wen Chong, Edmund Chiong, Ross Soo, Mi Kyoung Park, Hong Koo Ha, Jayantha Gunaratne, Jean Paul Thiery Oncotarget