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21 Dec 2020
BMRC
Institute of Molecular and Cell Biology
Remodelling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division
Jin Rong Ow,
Matias J Caldez,
Gözde Zafer,
Juat Chin Foo,
Hong Yu Li,
Soumita Ghosh,
Heike Wollmann,
Amaury Cazenave-Gassiot,
Chee Bing Ong,
Markus R Wenk,
Weiping Han,
Hyungwon Choi,
Philipp Kaldis
eLife
4 Nov 2020
BMRC
Institute of Molecular and Cell Biology
Loss of hepatocyte cell division leads to liver inflammation and fibrosis
Matthew R. Dewhurst,
Jin Rong Ow,
Gözde Zafer,
Noémi K. M. van Hul,
Heike Wollmann,
Xavier Bisteau,
David Brough,
Hyungwon Choi,
Philipp Kaldis
PLOS Genetics
16 Apr 2020
BMRC
Institute of Molecular and Cell Biology
Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia
Joel H. L. Tan,
Heike Wollmann,
Ans M.M. van Pelt,
Philipp Kaldis,
Daniel M. Messerschmidt
Stem Cell Reports
17 Dec 2019
BMRC
Institute of Molecular and Cell Biology
Discovery of a chemical probe for PRDM9
Abdellah Allali-Hassani,
Magdalena M. Szewczyk,
Danton Ivanochko,
Shawna L. Organ,
Jabez Bok,
Jessica Sook Yuin Ho,
Florence P. H. Gay,
Fengling Li,
Levi Blazer,
Mohammad S. Eram,
Levon Halabelian,
David Dilworth,
Genna M. Luciani,
Evelyne Lima-Fernandes,
Qin Wu,
Peter Loppnau,
Nathan Palmer,
S. Zakiah A. Talib,
Peter J. Brown,
Matthieu Schapira,
Philipp Kaldis,
Ronan C. O’Hagan,
Ernesto Guccione,
Dalia Barsyte-Lovejoy,
Cheryl H. Arrowsmith,
John M. Sanders,
Solomon D. Kattar,
D. Jonathan Bennett,
Benjamin Nicholson,
Masoud Vedadi
Nature Communications
13 Nov 2019
BMRC
Bioinformatics Institute
Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype
Joanna Niska-Blakie,
Lakshmi Gopinathan,
Kia Ngee Low,
Yang Lay Kien,
Christine M. F. Goh,
Matias J. Caldez,
Elisabeth Pfeiffenberger,
Oliver S. Jones,
Chee Bing Ong,
Igor V. Kurochkin,
Vincenzo Coppola,
Lino Tessarollo,
Hyungwon Choi,
Yoganathan Kanagasundaram,
Frank Eisenhaber,
Sebastian Maurer-Stroh,
Philipp Kaldis
Cellular and Molecular Life Sciences
26 Jul 2019
BMRC
Institute of Molecular and Cell Biology
CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I
Philipp Kaldis,
Nathan Palmer,
S. Zakiah A. Talib,
Chandrahas Koumar Ratnacaram,
Diana Low,
Xavier Bisteau,
Joanna Hui Si Lee,
Elisabeth Pfeiffenberger,
Heike Wollmann,
Joel Heng Loong Tan,
Sheena Wee,
Radoslaw Sobota,
Jayantha Gunaratne,
Daniel M. Messerschmidt,
Ernesto Guccione
Journal of Cell Biology
2 Apr 2019
BMRC
Institute of Molecular and Cell Biology
The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes
Victor S. Tapia,
Michael J. D. Daniels,
Pablo Palazón-Riquelme,
Matthew Dewhurst,
Nadia M. Luheshi,
Jack Rivers-Auty,
Jack Green,
Elena Redondo-Castro,
Philipp Kaldis,
Gloria Lopez-Castejon,
David Brough
Journal of Biological Chemistry
14 Dec 2018
BMRC
Institute of Molecular and Cell Biology
Loss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone
Akira Takahashi,
Mieradili Mulati,
Masanori Saito,
Hoashi Numata,
Yutaka Kobayashi,
Hiroki Ochi,
Shingo Sato,
Philipp Kaldis,
Atsushi Okawa,
Hiroyuki Inose
Journal of Biological Chemistry
18 Oct 2018
BMRC
Institute of Molecular and Cell Biology
Metabolic Remodeling during Liver Regeneration
Beatrice E. Chiang,
Walter Stunkel,
Hanry Yu,
Philip Lee,
Tobias Fuhrer,
Hyungwon Choi,
Mikael Björklund,
Philipp Kaldis,
Matias J. Caldez,
Noémi van Hul,
Hiromi W.L. Koh,
Xing Qi Teo,
Jun Jun Fan,
Peck Yean Tan,
Matthew R. Dewhurst,
Peh Gek Too,
S. Zakiah A. Talib
Developmental Cell
6 Sep 2018
BMRC
Institute of Molecular and Cell Biology
Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality
Radoslaw Szmyd,
Joanna Niska-Blakie,
M. Kasim Diril,
Patrícia Renck Nunes,
Konstantinos Tzelepis,
Aurélie Lacroix,
Noémi van Hul,
Lih-Wen Deng,
Joao Matos,
Oliver Dreesen,
Xavier Bisteau,
Philipp Kaldis
Oncogene
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