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23 Apr 2020 BMRC Bioinformatics Institute New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop Ruth A. Roberts, Thomas Steger-Hartmann, Evita Vanenbossche, Mark R. Viant, Matthieu Vinken, Maurice Whelan, Zvonar Zvonimir, Mark T. D. Cronin, Catherine Mahony, Randolph S. Ashton, Barbara Birk, Alan R. Boobis, Tom Cull, George P. Daston, Lorna Ewart, Thomas B. Knudsen, Irene Manou, Sebastian Maurer-Stroh, Luigi Margiotta-Casaluci, Boris P. Muller, Pär Nordlund
18 Dec 2019 BMRC Institute of Molecular and Cell Biology CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance Anette Langebäck, Smaranda Bacanu, Henriette Laursen, Lisanne Mout, Takahiro Seki, Sigrun Erkens-Schulze, Anderson Daniel Ramos, Anna Berggren, Yihai Cao, Johan Hartman, Wytske van Weerden, Jonas Bergh, Pär Nordlund, Sara Lööf
2 Apr 2019 BMRC Institute of Molecular and Cell Biology Horizontal Cell Biology: Monitoring Global Changes of Protein Interaction States with the Proteome-Wide Cellular Thermal Shift Assay (CETSA) Lingyun Dai, Nayana Prabhu, Liang Ying Yu, Smaranda Bacanu, Anderson Daniel Ramos, Pär Nordlund
14 Mar 2019 BMRC Institute of Molecular and Cell Biology Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA Wendi Sun, Lingyun Dai, Han Yu, Brenda Puspita, Tianyun Zhao, Feng Li, Justin L. Tan, Yan Ting Lim, Ming Wei Chen, Radoslaw M. Sobota, Daniel G. Tenen, Nayana Prabhu, Pär Nordlund
26 Apr 2018 BMRC Institute of Molecular and Cell Biology Modulation of Protein-Interaction States through the Cell Cycle Lingyun Dai, Tianyun Zhao, Xavier Bisteau, Wendi Sun, Nayana Prabhu, Yan Ting Lim, Radoslaw M. Sobota, Philipp Kaldis, Pär Nordlund
19 Dec 2017 BMRC Institute of Molecular and Cell Biology Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality Mayumi Kitagawa, Pei-Ju Liao, Kyung Hee Lee, Jasmine Wong, See Cheng Shang, Noriaki Minami, Oltea Sampetrean, Hideyuki Saya, Dai Lingyun, Nayana Prabhu, Go Ka Diam, Radoslaw Sobota, Andreas Larsson, Pär Nordlund, Frank McCormick, Sujoy Ghosh, David M. Epstein, Brian W. Dymock, Sang Hyun Lee
6 Jan 2016 BMRC Institute of Molecular and Cell Biology The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies Daniel Martinez Molina, Pär Nordlund
2 Dec 2015 BMRC Institute of Molecular and Cell Biology Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine Tobias Cornvik, Pär Nordlund, Anna Roujeinikova, Kelly Hew, Sue-Li Dahlroth, Saranya Veerappan, Lucy Xin Pan
10 Jul 2015 BMRC p53 Laboratory Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays Ban Xiong Tan, Christopher J. Brown, Fernando J. Ferrer, Tze Ying Yuen, Soo Tng Quah, Boon Hong Chan, Anna E. Jansson, Hsiang Ling Teo, Pär Nordlund, David P. Lane
17 Jun 2015 BMRC Institute of Molecular and Cell Biology Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1 T. S. Dermody, Vidhi Patel, Sue-Li Dahlroth, Venkatachalam Rajakannan, Hai Ting Ho, Tobias Cornvik, Pär Nordlund