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Publication date Communities Collections Article title Author(s) Journal/Conference
21 Dec 2020 BMRC Institute of Molecular and Cell Biology Remodelling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division Jin Rong Ow, Matias J Caldez, Gözde Zafer, Juat Chin Foo, Hong Yu Li, Soumita Ghosh, Heike Wollmann, Amaury Cazenave-Gassiot, Chee Bing Ong, Markus R Wenk, Weiping Han, Hyungwon Choi, Philipp Kaldis eLife
4 Nov 2020 BMRC Institute of Molecular and Cell Biology Loss of hepatocyte cell division leads to liver inflammation and fibrosis Matthew R. Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K. M. van Hul, Heike Wollmann, Xavier Bisteau, David Brough, Hyungwon Choi, Philipp Kaldis PLOS Genetics
16 Apr 2020 BMRC Institute of Molecular and Cell Biology Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia Joel H. L. Tan, Heike Wollmann, Ans M.M. van Pelt, Philipp Kaldis, Daniel M. Messerschmidt Stem Cell Reports
17 Dec 2019 BMRC Institute of Molecular and Cell Biology Discovery of a chemical probe for PRDM9 Abdellah Allali-Hassani, Magdalena M. Szewczyk, Danton Ivanochko, Shawna L. Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P. H. Gay, Fengling Li, Levi Blazer, Mohammad S. Eram, Levon Halabelian, David Dilworth, Genna M. Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S. Zakiah A. Talib, Peter J. Brown, Matthieu Schapira, Philipp Kaldis, Ronan C. O’Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, John M. Sanders, Solomon D. Kattar, D. Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi Nature Communications
13 Nov 2019 BMRC Bioinformatics Institute Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype Joanna Niska-Blakie, Lakshmi Gopinathan, Kia Ngee Low, Yang Lay Kien, Christine M. F. Goh, Matias J. Caldez, Elisabeth Pfeiffenberger, Oliver S. Jones, Chee Bing Ong, Igor V. Kurochkin, Vincenzo Coppola, Lino Tessarollo, Hyungwon Choi, Yoganathan Kanagasundaram, Frank Eisenhaber, Sebastian Maurer-Stroh, Philipp Kaldis Cellular and Molecular Life Sciences
26 Jul 2019 BMRC Institute of Molecular and Cell Biology CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I Philipp Kaldis, Nathan Palmer, S. Zakiah A. Talib, Chandrahas Koumar Ratnacaram, Diana Low, Xavier Bisteau, Joanna Hui Si Lee, Elisabeth Pfeiffenberger, Heike Wollmann, Joel Heng Loong Tan, Sheena Wee, Radoslaw Sobota, Jayantha Gunaratne, Daniel M. Messerschmidt, Ernesto Guccione Journal of Cell Biology
2 Apr 2019 BMRC Institute of Molecular and Cell Biology The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes Victor S. Tapia, Michael J. D. Daniels, Pablo Palazón-Riquelme, Matthew Dewhurst, Nadia M. Luheshi, Jack Rivers-Auty, Jack Green, Elena Redondo-Castro, Philipp Kaldis, Gloria Lopez-Castejon, David Brough Journal of Biological Chemistry
14 Dec 2018 BMRC Institute of Molecular and Cell Biology Loss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone Akira Takahashi, Mieradili Mulati, Masanori Saito, Hoashi Numata, Yutaka Kobayashi, Hiroki Ochi, Shingo Sato, Philipp Kaldis, Atsushi Okawa, Hiroyuki Inose Journal of Biological Chemistry
18 Oct 2018 BMRC Institute of Molecular and Cell Biology Metabolic Remodeling during Liver Regeneration Beatrice E. Chiang, Walter Stunkel, Hanry Yu, Philip Lee, Tobias Fuhrer, Hyungwon Choi, Mikael Björklund, Philipp Kaldis, Matias J. Caldez, Noémi van Hul, Hiromi W.L. Koh, Xing Qi Teo, Jun Jun Fan, Peck Yean Tan, Matthew R. Dewhurst, Peh Gek Too, S. Zakiah A. Talib Developmental Cell
6 Sep 2018 BMRC Institute of Molecular and Cell Biology Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality Radoslaw Szmyd, Joanna Niska-Blakie, M. Kasim Diril, Patrícia Renck Nunes, Konstantinos Tzelepis, Aurélie Lacroix, Noémi van Hul, Lih-Wen Deng, Joao Matos, Oliver Dreesen, Xavier Bisteau, Philipp Kaldis Oncogene
26 Apr 2018 BMRC Institute of Molecular and Cell Biology Modulation of Protein-Interaction States through the Cell Cycle Lingyun Dai, Tianyun Zhao, Xavier Bisteau, Wendi Sun, Nayana Prabhu, Yan Ting Lim, Radoslaw M. Sobota, Philipp Kaldis, Pär Nordlund Cell
9 Mar 2018 BMRC Institute of Molecular and Cell Biology Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells Chris Soon Heng Tan, Ka Diam Go, Xavier Bisteau, Lingyun Dai, Chern Han Yong, Nayana Prabhu, Mert Burak Ozturk, Yan Ting Lim, Lekshmy Sreekumar, Johan Lengqvist, Vinay Tergaonkar, Philipp Kaldis, Radoslaw M. Sobota, Pär Nordlund Science
28 Sep 2017 BMRC Institute of Molecular and Cell Biology Cell size control – a mechanism for maintaining fitness and function Teemu P. Miettinen, Matias J. Caldez, Philipp Kaldis, Mikael Björklund Bioessays
7 Sep 2017 BMRC Institute of Molecular and Cell Biology CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays Katharina Roetzer, Paul Roschger, Klaus Klaushofer, Janine Altmüller, Sudipto Roy, Byrappa Venkatesh, Rudolf Ganger, Franz Grill, Christian Windpassinger, Juliette Piard, Carine Bonnard, Majid Alfadhel, Shuhui Lim, Xavier Bisteau, Verena Rupp, Stéphane Blouin, Nur’Ain B. Ali, Alvin Yu Jin Ng, Hao Lu, Sumanty Tohari, S. Zakiah A. Talib, Noémi van Hul, Matias J. Caldez, Lionel Van Maldergem, Gökhan Yigit, Hulya Kayserili, Sameh A. Youssef, Vincenzo Coppola, Alain de Bruin, Lino Tessarollo, Hyungwon Choi, Farid Ben Chehida, Bernd Wollnik, Umut Altunoglu, Ali Al Kaissi, Bruno Reversade, Philipp Kaldis American Journal of Human Genetics (AJHG)
28 Jul 2017 BMRC Institute of Molecular and Cell Biology Cyclin-Dependent Kinase-Dependent Phosphorylation of Sox2 at Serine 39 Regulates Neurogenesis Shuhui Lim, Akshay Bhinge, Sara Bragado Alonso, Irene Aksoy, Julieta Aprea, Chit Fang Cheok, Federico Calegari, Lawrence W. Stanton, Philipp Kaldis Molecular and Cellular Biology
29 Sep 2016 BMRC Bioinformatics Institute Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function Roland G. Huber, Irina Kulemzina, Keven Ang, Alap P. Chavda, Sasikala Suranthran, Jun-Thing Teh, Dimitar Kenanov, Gaowen Liu, Giulia Rancati, Radoslaw Szmyd, Philipp Kaldis, Peter J. Bond, Dmitri Ivanov Structure
23 Nov 2015 BMRC Institute of Molecular and Cell Biology A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity Anne Margriet Heijink, Vincent A. Blomen, Xavier Bisteau, Fabian Degener, Felipe Yu Matsushita, Philipp Kaldis, Floris Foijer, Marcel A. T. M. van Vugt Proceedings of the National Academy of Sciences
1 Aug 2015 BMRC Institute of Molecular and Cell Biology Mastl/PP2A regulate Cdk1 in ooycte maturation Deepak Adhikari, Kui Liu, Philipp Kaldis Oncotarget
23 Jul 2015 BMRC Institute of Molecular and Cell Biology TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression Victor Ho, Tong Seng Lim, Justin Lee, Jeffrey Steinberg, Radoslaw Szmyd, Muly Tham, Jadegoud Yaligar, Philipp Kaldis, Jean-Pierre Abastado, Valerie Chew Oncotarget
4 Sep 2014 BMRC Institute of Molecular and Cell Biology Spy1/SpeedyA accelerates neuroblastoma Xavier Bisteau, Philipp Kaldis Oncotarget
17 Mar 2014 BMRC Institute of Molecular and Cell Biology Identification of Transcriptional and Metabolic Programs Related to Mammalian Cell Size Teemu P. Miettinen, Heli K.J. Pessa, Matias J. Caldez, Tobias Fuhrer, M. Kasim Diril, Uwe Sauer, Philipp Kaldis, Mikael Björklund Current Biology
28 Feb 2014 BMRC Institute of Molecular and Cell Biology IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice Deborah L. Hodge, Cyril Berthet, Vincenzo Coppola, Wolfgang Kastenmüller, Matthew D. Buschman, Paul M. Schaughency, Hidekazu Shirota, Anthony J. Scarzello, Jeff J. Subleski, Miriam R. Anver, John R. Ortaldo, Fanching Lin, Della A. Reynolds, Michael E. Sanford, Philipp Kaldis, Lino Tessarollo, Dennis M. Klinman, Howard A. Young Journal of Autoimmunity
17 Feb 2014 BMRC Institute of Molecular and Cell Biology MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2 M P Gillam, D Nimbalkar, L Sun, K Christov, D Ray, P Kaldis, X Liu, H Kiyokawa Oncogene
1 Feb 2014 BMRC Institute of Medical Biology p27 is regulated independently of Skp2 in the absence of Cdk2 Shuhei Kotoshiba, Lakshmi Gopinathan, Elisabeth Pfeiffenberger, Anisa Rahim, Leah A. Vardy, Keiko Nakayama, Keiichi I. Nakayama, Philipp Kaldis Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
13 Jan 2014 BMRC Institute of Molecular and Cell Biology The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations Xavier Bisteau, Matias Caldez, Philipp Kaldis Cancers
1 Dec 2013 BMRC Institute of Molecular and Cell Biology Cyclin E1 regulates hematopoietic stem cell quiescence Senthil Raja Jayapal, Philipp Kaldis Cell Cycle
8 Aug 2013 BMRC Institute of Molecular and Cell Biology Cdks, cyclins and CKIs: roles beyond cell cycle regulation Philipp Kaldis, Shuhui Lim Development
18 Jun 2012 BMRC Institute of Molecular and Cell Biology Loss of Cdk2 and Cdk4 Induces a Switch from Proliferation to Differentiation in Neural Stem Cells Shuhui Lim, Philipp Kaldis STEM CELLS
5 Jan 2012 BMRC Genome Institute of Singapore Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis John Tam, Agasthian Thirugananam, Monireh Soroush Noghabi, Yin Huei Pang, Haw Siang Ang, Wayne Mitchell, Paul Robson, Philipp Kaldis, Ross Andrew Soo, Sanjay Swarup, Elaine Hsuen Lim, Bing Lim, Wen Cai Zhang, Ng Shyh-Chang, He Yang, Amit Rai, Shivshankar Umashankar, Siming Ma, Boon Seng Soh, Li Li Sun, Bee Choo Tai, Min En Nga, Kishore Kumar Bhakoo, Senthil Raja Jayapal, Massimo Nichane, Qiang Yu, Dokeu A. Ahmed, Christie Tan, Wong Poo Sing Cell
5 Mar 2010 BMRC p53 Laboratory Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53 C F Cheok, N Kua, P Kaldis, D P Lane Cell Death and Differentiation
1 May 2006 BMRC Institute of Molecular and Cell Biology Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation Cyril Berthet, Kimberly D. Klarmann, Mary Beth Hilton, Hyung Chan Suh, Jonathan R. Keller, Hiroaki Kiyokawa, Philipp Kaldis Developmental Cell