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Publication date Communities Collections Article title Author(s) Journal/Conference
8 Feb 2022 BMRC Institute of Bioengineering and Nanotechnology Dye‐Conjugated Spinach RNA by Genetic Alphabet Expansion Kyung Hyun Lee, Michiko Kimoto, Gota Kawai, Itaru Okamoto, Andrea Fin, Ichiro Hirao Chemistry – A European Journal
9 Sep 2021 BMRC Institute of Bioengineering and Bioimaging Competitive ELISA for a serologic test to detect dengue serotype-specific anti-NS1 IgGs using high-affinity UB-DNA aptamers Ken-ichiro Matsunaga, Michiko Kimoto, Vanessa Weixun Lim, Tun-Linn Thein, Shawn Vasoo, Yee-Sin Leo, William Sun, Ichiro Hirao Scientific Reports
24 Jul 2021 BMRC Institute of Bioengineering and Bioimaging Uptake mechanisms of cell-internalizing nucleic acid aptamers for applications as pharmacological agents Samira Husen Alamudi, Michiko Kimoto, Ichiro Hirao RSC Medicinal Chemistry
25 Jun 2021 BMRC Institute of Bioengineering and Bioimaging High-affinity five/six-letter DNA aptamers with superior specificity enabling the detection of dengue NS1 protein variants beyond the serotype identification Ken-ichiro Matsunaga, Michiko Kimoto, Vanessa Weixun Lim, Hui Pen Tan, Yu Qian Wong, William Sun, Shawn Vasoo, Yee Sin Leo, Ichiro Hirao Nucleic Acids Research
7 Nov 2020 BMRC Institute of Bioengineering and Nanotechnology Genetic alphabet expansion technology by creating unnatural base pairs. Michiko Kimoto, Ichiro Hirao Chemical Society Reviews
6 Nov 2020 BMRC Institute of Bioengineering and Nanotechnology Cognate base-pair selectivity of hydrophobic unnatural bases in DNA ligation by T4 DNA ligase Michiko Kimoto, Si Hui Gabriella Soh, Hui Pen Tan, Itaru Okamoto, Ichiro Hirao Biopolymers
23 Mar 2020 BMRC Institute of Bioengineering and Bioimaging Sanger Gap Sequencing for Genetic Alphabet Expansion of DNA Michiko Kimoto, Si Hui Gabriella Soh, Ichiro Hirao ChemBioChem
22 Mar 2020 BMRC Institute of Bioengineering and Nanotechnology Sanger Gap Sequencing for Genetic Alphabet Expansion of DNA Michiko Kimoto, Si Hui Gabriella Soh, Ichiro Hirao ChemBioChem
8 Aug 2019 BMRC Institute of Bioengineering and Nanotechnology Molecular affinity rulers: systematic evaluation of DNA aptamers for their applicabilities in ELISA Michiko Kimoto, Yun Wei Shermane Lim, Ichiro Hirao Nucleic Acids Research
17 Apr 2019 BMRC Institute of Bioengineering and Nanotechnology DNA sequencing method including unnatural bases for DNA aptamer generation by genetic alphabet expansion Kiyofumi Hamashima, Yun Ting Soong, Ken-ichiro Matsunaga, Michiko Kimoto, Ichiro Hirao ACS Synthetic Biology
28 Nov 2018 BMRC Institute of Bioengineering and Nanotechnology Genetic Alphabet Expansion Provides Versatile Specificities and Activities of Unnatural-base DNA Aptamers Targeting Cancer Cells Kazunobu Futami, Michiko Kimoto, Yun Wei Shermane Lim, Ichiro Hirao Molecular Therapy Nucleic Acids
15 Oct 2018 BMRC Institute of Bioengineering and Nanotechnology Visual Detection of Amplified DNA by PCR using a Genetic Alphabet Expansion System Rie Yamashige, Michiko Kimoto, Ryo Okumura, Ichiro Hirao Journal of the American Chemical Society
27 Jul 2018 BMRC Institute of Bioengineering and Nanotechnology Creation of unnatural base pairs for genetic alphabet expansion toward synthetic xenobiology Kiyofumi Hamashima, Michiko Kimoto, Ichiro Hirao Current Opinion in Chemical Biology
13 Feb 2018 BMRC Institute of Bioengineering and Nanotechnology Evolving aptamers with unnatural base pairs Ichiro Hirao, Michiko Kimoto, Ken-ichiro Matsunaga Current Protocols in Chemical Biology
25 Oct 2017 BMRC Institute of Bioengineering and Nanotechnology Genetic alphabet expansion transcription generating functional RNA molecules containing a five-letter alphabet including modified unnatural and natural base nucleotides by thermostable T7 RNA polymerase variants Michiko Kimoto, Adam J. Meyer, Ichiro Hirao, Andrew D. Ellington Chemical Communications
16 Oct 2017 BMRC Institute of Bioengineering and Nanotechnology Genetic alphabet expansion biotechnology by creating unnatural base pairs Kyung Hyun Lee, Kiyofumi Hamashima, Michiko Kimoto, Ichiro Hirao Current Opinion in Biotechnology
13 Sep 2017 BMRC Institute of Bioengineering and Nanotechnology DNA aptamer generation by ExSELEX using genetic alphabet expansion with a mini-hairpin DNA stabilization method Ichiro Hirao, Michiko Kimoto, Kyung Hyun Lee Biochimie
26 Jul 2017 BMRC Institute of Bioengineering and Nanotechnology Unique Thermal Stability of Unnatural Hydrophobic Ds Bases in Double-Stranded DNAs Michiko Kimoto, Ichiro Hirao ACS Synthetic Biology
8 Jun 2017 BMRC Institute of Bioengineering and Nanotechnology Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair Karin Betz, Michiko Kimoto, Kay Diederichs, Ichiro Hirao, Andreas Marx Angewandte Chemie International Edition
28 Dec 2016 BMRC Institute of Bioengineering and Nanotechnology High-Affinity DNA Aptamer Generation Targeting von Willebrand Factor A1-Domain by Genetic Alphabet Expansion for Systematic Evolution of Ligands by Exponential Enrichment Using Two Types of Libraries Composed of Five Different Bases. Ken-ichiro Matsunaga, Michiko Kimoto, Ichiro Hirao Journal of the American Chemical Society
7 Jul 2016 BMRC Institute of Bioengineering and Nanotechnology Post-ExSELEX stabilization of an unnatural-base DNA aptamer targeting VEGF165 toward pharmaceutical applications Michiko Kimoto, Nama Nakamura, Ichiro Hirao Nucleic Acids Research