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11 May 2020
BMRC
Bioinformatics Institute
Macrocyclization of an all-D linear α-helical peptide imparts cellular permeability
Srinivasaraghavan Kannan,
Pietro G. A. Aronica,
Simon Ng,
Dawn Thean Gek Lian,
Yuri Frosi,
Sharon Chee,
Shimin Jiang,
Tsz Ying Yuen,
Ahmad Sadruddin,
Hung Yi Kristal Kaan,
Arun Chandramohan,
Yi Han,
Jin Huei Wong,
Yaw Sing Tan,
Zi Wei Chang,
Fernando Jose Ferrer-Gago,
Prakash Arumugam,
Shiying Chen,
Laurent Claude Stephane Renia,
Christopher J. Brown,
Charles W. Johannes,
Brian Henry,
David P. Lane,
Tomi K Sawyer,
Chandra S. Verma,
Anthony William Patridge
Chemical Science
5 May 2020
BMRC
Bioinformatics Institute
De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits
Simon Ng,
Yu-Chi Juang,
Arun Chandramohan,
Hung Yi Kristal Kaan,
Ahmad Sadruddin,
Tsz Ying Yuen,
Fernando J. Ferrer-Gago,
Xue'Er Cheryl Lee,
Liew Xi,
Charles W. Johanes,
Christopher J. Brown,
Srinivasaraghavan Kanan,
Pietro G. Aronica,
Nils A. Berglund,
Chandra S. Verma,
Lijuan Liu,
Alexander Stoeck,
Tomi K. Sawyer,
Anthony W. Partridge,
David P. Lane
ACS Medicinal Chemistry Letters
20 Jun 2019
BMRC
Bioinformatics Institute
Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties
Anthony W. Patridge,
Hung Yi Kristal Kaan,
Yu-Chi Juang,
Ahmad Sadruddin,
Shuhui Lim,
Christopher J. Brown,
Simon Ng,
Dawn Thean,
Fernando Ferrer,
Charles Johannes,
Tsz Ying Yuen,
Srinivasaraghavan Kannan,
Pietro Aronica,
Yaw Sing Tan,
Mohan R. Praddhan,
Chandra S. Verma,
Jerome Hochman,
Shiying Chen,
Hui Wan,
Sookhee Ha,
Brad Sherbone,
David P. Lane,
Tomi K. Sawyer
Molecules
30 May 2019
BMRC
p53 Laboratory
Stereoisomerism of Stapled Peptide Inhibitors of the p53-Mdm2 Interaction: An Assessment of Synthetic Strategies and Activity Profiles
Tsz Ying Yuen,
Christopher J. Brown,
Yuezhen Xue,
Yaw Sing Tan,
Fernando J. Ferrer Gago,
Xue Er Lee,
Jin Yong Neo,
Dawn Thean,
Hung Yi Kristal Kaan,
Anthony W. Partridge,
Chandra S. Verma,
David P. Lane,
Charles W. Johannes
Chemical Science
30 May 2019
BMRC
Bioinformatics Institute
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles
Tsz Ying Yuen,
Christopher J. Brown,
Yuezhen Xue,
Yaw Sing Tan,
Fernando J. Ferrer Gago,
Xue Er Lee,
Jin Yong Neo,
Dawn Thean,
Hung Yi Kristal Kaan,
Anthony W. Partridge,
Chandra S. Verma,
David P. Lane,
Charles A. Johannes
Chemical Science
30 May 2019
SERC
Institute of Chemical and Engineering Sciences
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles
Tsz Ying Yuen,
Christopher J. Brown,
Yuezhen Xue,
Yaw Sing Tan,
Fernando J. Ferrer Gago,
Xue Er Lee,
Jin Yong Neo,
Dawn Thean,
Hung Yi Kristal Kaan,
Anthony W. Partridge,
Chandra S. Verma,
David P. Lane,
Charles W. Johannes
Chemical Science
1 Jun 2017
BMRC
Institute of Molecular and Cell Biology
Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches
Siew Kim Joyce Tan,
Chandra Verma,
Hung Yi Kristal Kaan,
Adelene Y. L. Sim,
Haiwei Song
PLOS One
17 May 2017
BMRC
Institute of Molecular and Cell Biology
Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex
Fusheng Guo,
Chun Jye Lim,
Hung Yi Kristal Kaan,
Siew Wee Chan,
Siew Kim Joyce Tan,
Wanjin Hong,
Haiwei Song
Scientific Reports
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