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29 Sep 2020 BMRC Bioinformatics Institute Structural Modelling of the Lumenal Domain of Human GPAA1, the Metallo-Peptide Synthetase Subunit of the Transamidase Complex, Reveals Zinc-Binding Mode and Two Flaps Surrounding the Active Site Tran-To Su Su, Swati Sinha, Birgit Eisenhaber, Frank Eisenhaber
19 Mar 2020 BMRC Bioinformatics Institute Identification and engineering of 32 membered antifungal macrolactone notonesomycins Falicia Goh, Mingzi M. Zhang, Tian Ru Lim, Kia Ngee Low, Choy Eng Nge, Elena Heng, Wan Lin Yeo, Fernanda L. Sirota, Sharon Crasta, Zann Tan, Veronica Ng, Chung Yan Leong, Hubin Zhang, Alexander Lezhava, Swaine L. Chen, Shawn S. Hoon, Frank Eisenhaber, Birgit Eisenhaber, Yoganathan Kanagasundaram, Fong T. Wong, Siew Bee Ng
12 Dec 2019 BMRC Bioinformatics Institute In Memory of Vladimir B. Bajic (1952–2019) Zhang Zhang, Jun Yu, Frank Eisenhaber, Xin Gao, Takashi Gojobori
13 Nov 2019 BMRC Bioinformatics Institute Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype Joanna Niska-Blakie, Lakshmi Gopinathan, Kia Ngee Low, Yang Lay Kien, Christine M. F. Goh, Matias J. Caldez, Elisabeth Pfeiffenberger, Oliver S. Jones, Chee Bing Ong, Igor V. Kurochkin, Vincenzo Coppola, Lino Tessarollo, Hyungwon Choi, Yoganathan Kanagasundaram, Frank Eisenhaber, Sebastian Maurer-Stroh, Philipp Kaldis
3 Aug 2019 BMRC Bioinformatics Institute Translational Informatics Management System (TIMS): Towards OMICS based clinical data management for long term curation of clinical studies Weihong Tay, Erwin Tantoso, Frank Eisenhaber, Wing-Cheong Wong
1 Jun 2019 BMRC Bioinformatics Institute Hypocrisy Around Medical Patient Data: Issues of Access for Biomedical Research, Data Quality, Usefulness for the Purpose and Omics Data as Game Changer Erwin Tantoso, Wing-Cheong Wong, Wei Hong Tay, Joanne Lee, Swati Sinha, Birgit Eisenhaber, Frank Eisenhaber
14 May 2019 BMRC Bioinformatics Institute Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723 Swati Sinha, Choy-Eng Nge, Chung Yan Leong, Veronica Ng, Sharon Crasta, Mohammad Alfatah, Falicia Goh, Kia-Ngee Low, Huibin Zhang, Prakash Arumugam, Alexander Lezhava, Swaine L. Chen, Yoganathan Kanagasundaram, Siew Bee Ng, Frank Eisenhaber, Birgit Eisenhaber
30 Apr 2019 BMRC Bioinformatics Institute Effect of the additional cysteine 503 of vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit F (AhpF) and the mechanism of AhpF and subunit C assembling Yew Kwang Toh, Joon Shin, Asha Manikkoth Balakrishna, Neelagandan Kamariah, Ardina Gruber, Frank Eisenhaber, Birgit Eisenhaber, Gerhard Gruber
18 Jan 2019 BMRC Bioinformatics Institute AllerCatPro - Prediction of protein allergenicity potential from the protein sequence Sebastian Maurer-Stroh, Nora L. Krutz, Petra S. Kern, Vithiagaran Gunalan, Minh N. Nguyen, Vachiranee Limviphuvadh, Frank Eisenhaber, G. Frank Gerberick
27 Nov 2018 BMRC Bioinformatics Institute The Geographic Variation of Surveillance and Zoonotic Spillover Potential of Influenza Viruses in Domestic Poultry and Swine Kathryn A. Berger, David M. Pigott, Francesca Tomlinson, David Godding, Sebastian Maurer-Stroh, Biruhalem Taye, Fernanda L. Sirota, Alvin Han, Raphael T. C. Lee, Vithiagaran Gunalan, Frank Eisenhaber, Simon I. Hay, Colin A. Russell
30 Oct 2018 BMRC Bioinformatics Institute Darkness in the Human Gene and Protein Function Space: Widely Modest or Absent Illumination by the Life Science Literature and the Trend for Fewer Protein Function Discoveries Since 2000 Swati Sinha, Birgit Eisenhaber, Lars Juhl Jensen, Bharata Kalbuaji, Frank Eisenhaber
20 Sep 2018 BMRC Bioinformatics Institute Molecular mechanism of the Escherichia coli AhpC in the function of a chaperone under heat-shock conditions Neelagandan Kamariah, Birgit Eisenhaber, Frank Eisenhaber, Gerhard Gruber
21 May 2018 BMRC Bioinformatics Institute Isolation and Identification of an Anthracimycin Analogue from Nocardiopsis kunsanensis, a Halophile from a Saltern, by Genomic Mining Strategy Fernanda L. Sirota, Falicia Goh, Kia-Ngee Low, Lay-Kien Yang, Sharon C. Crasta, Birgit Eisenhaber, Frank Eisenhaber, Yoganathan Kanagasundaram, Siew Bee Ng
21 May 2018 BMRC Bioinformatics Institute Isolation and Identification of an Anthracimycin Analogue from Nocardiopsis kunsanensis, a Halophile from a Saltern, by Genomic Mining Strategy Fernanda L. Sirota, Falicia Goh, Kia-Ngee Low, Lay-Kien Yang, Sharon C. Crasta, Birgit Eisenhaber, Frank Eisenhaber, Yoganathan Kanagasundaram, Siew Bee Ng
15 May 2018 BMRC Bioinformatics Institute Function of a membrane-embedded domain evolutionarily multiplied in the GPI lipid anchor pathway proteins PIG-B, PIG-M, PIG-U, PIG-W, PIG-V, and PIG-Z. Birgit Eisenhaber, Swati Sinha, Wing-Cheong Wong, Frank Eisenhaber
11 May 2018 BMRC Bioinformatics Institute Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy Vachiranee Limviphuvadh, Chee Seng Tan, Fumikazu Konishi, Piroon Jenjaroenpun, Joy Shengnan Xiang, Yuliya Kremenska, Yar Soe Mu, Syn Nicholas, Lee Soo Chin, Ross A. Soo, Frank Eisenhaber, Sebastian Maurer-Stroh, Wei Peng Yong
21 Feb 2018 BMRC Bioinformatics Institute Active site C P -loop dynamics modulate substrate binding, catalysis, oligomerization, stability, over-oxidation and recycling of 2-Cys Peroxiredoxins Neelagandan Kamariah, Birgit Eisenhaber, Frank Eisenhaber, Gerhard Gruber
12 Feb 2018 BMRC Bioinformatics Institute Finite-size effects in transcript sequencing count distribution: its power-law correction necessarily precedes downstream normalization and comparative analysis Wing-Cheong Wong, Hong-kiat Ng, Erwin Tantoso, Richie Soong, Frank Eisenhaber
8 Feb 2017 BMRC Bioinformatics Institute Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it Wai-Heng Lua, Wei-Li Ling, Chinh Tran-To Su, Joshua Yi Yeo, Chandra S. Verma, Birgit Eisenhaber, Frank Eisenhaber, Samuel Ken-En Gan
29 Nov 2016 BMRC Bioinformatics Institute xHMMER3x2: Utilizing HMMER3’s speed and HMMER2’s sensitivity and specificity in the glocal alignment mode for improved large-scale protein domain annotation Choon-Kong Yap, Birgit Eisenhaber, Frank Eisenhaber, Wing-Cheong Wong
28 Nov 2016 BMRC Bioinformatics Institute Transition steps in peroxide reduction and a molecular switch for peroxide robustness of prokaryotic peroxiredoxins Neelagandan Kamariah, Mun Foong Sek, Birgit Eisenhaber, Frank Eisenhaber, Gerhard Gruber
15 Sep 2016 BMRC Bioinformatics Institute A Reversible Association between Smc Coiled Coils Is Regulated by Lysine Acetylation and Is Required for Cohesin Association with the DNA Irina Kulemzina, Keven Ang, Xiaodan Zhao, Jun-Thing Teh, Vikash Verma, Sasikala Suranthran, Alap P. Chavda, Roland G. Huber, Birgit Eisenhaber, Frank Eisenhaber, Jie Yan, Dmitri Ivanov
24 Sep 2015 BMRC Bioinformatics Institute NMR studies reveal a novel grab and release mechanism for efficient catalysis of the bacterial 2-Cys peroxiredoxin machinery Wilson Nartey, Sandip Basak, Neelagandan Kamariah, Malathy S. S. Manimekalai, Scott Robson, Gerhard Wagner, Birgit Eisenhaber, Frank Eisenhaber, Gerhard Gruber
8 Dec 2014 BMRC Bioinformatics Institute Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients Tzia Liang Mah, Xin Ning Adeline Yap, Vachiranee Limviphuvadh, Nanpu Li, Srinath Sridharan, Vellaisemy Kuralmani, Mengling Feng, Natalia Liem, Sharmila Adhikari, Wei Peng Yong, Ross A Soo, Sebastian Maurer-Stroh, Frank Eisenhaber, Joo Chuan Tong
13 Dec 2013 BMRC Bioinformatics Institute International Conference on Genome Informatics (GIW 2013) in Singapore: introduction to the systems biology contributions Frank Eisenhaber, Wing-Kin Sung, Limsoon Wong
10 Dec 2013 BMRC Bioinformatics Institute Automatic phylogenetic classification of bacterial beta-lactamase sequences including structural and antibiotic substrate preference information Jianmin Ma, Frank Eisenhaber, Sebastian Maurer-Stroh
2 Dec 2013 BMRC Bioinformatics Institute A simple shortcut to unsupervised alignment-free phylogenetic genome groupings, even from unassembled sequencing reads Sebastian Maurer-Stroh, Vithiagaran Gunalan, Wing-Cheong Wong, Frank Eisenhaber
26 Oct 2013 BMRC Bioinformatics Institute A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus Vithiagaran Gunalan, Thanh Dac Van, Ly Thi Le, Frank Eisenhaber, Sebastian Maurer-Stroh, Raphael Tze Chuen Lee
1 May 2013 BMRC Bioinformatics Institute The highly pathogenic H7N3 avian influenza strain from July 2012 in Mexico acquired an extended cleavage site through recombination with host 28S rRNA Sebastian Maurer-Stroh, Raphael TC Lee, Vithiagaran Gunalan, Frank Eisenhaber
10 Jan 2013 BMRC Bioinformatics Institute How bioinformatics influences health informatics: usage of biomolecular sequences, expression profiles and automated microscopic image analyses for clinical needs and public health Hwee Kuan Lee, Sebastian Maurer-Stroh, Maria Judit Molnár, Sandor Pongor, Birgit Eisenhaber, Frank Eisenhaber, Vladimir Kuznetsov
25 Oct 2011 BMRC Bioinformatics Institute Not all transmembrane helices are born equal: Towards the extension of the sequence homology concept to membrane proteins Frank Eisenhaber, Wing-Cheong Wong, Sebastian Maurer-Stroh
1 Nov 2010 BMRC Bioinformatics Institute All that glitters is not gold - founder effects complicate associations of flu mutations to disease severity Lin Cui, Fernanda L Sirota, Raphael TC Lee, Cecília LS Santos, Terezinha Maria de Paiva, Frank Eisenhaber, Sebastian Maurer-Stroh
24 Sep 2010 BMRC Bioinformatics Institute Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2 Vachiranee Limviphuvadh, Ling Ling Chua, Rabi 'Atul' Adawiyah Bte Rahim, Frank Eisenhaber, Sebastian Maurer-Stroh, Sharmila Adhikari
20 May 2009 BMRC Bioinformatics Institute Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites Sebastian Maurer-Stroh, Jianmin Ma, Raphael Lee, Fernanda L Sirota, Frank Eisenhaber